Cargando…
Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database?
BACKGROUND: There has been lack of guidance for stratify treatment between cervical endometrioid adenocarcinoma (EC) and ordinary cervical adenocarcinoma (AC), therefore understanding the difference of prognosis between EC and AC is important for individualized therapy for these patients. METHODS: I...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273663/ https://www.ncbi.nlm.nih.gov/pubmed/35836529 http://dx.doi.org/10.21037/tcr-22-1180 |
_version_ | 1784745126144245760 |
---|---|
author | Zhang, Fubin Jin, Bohong Yan, Hui Zhu, Tianhong Ding, Huiqing Chen, Xueqin Guan, Yutao |
author_facet | Zhang, Fubin Jin, Bohong Yan, Hui Zhu, Tianhong Ding, Huiqing Chen, Xueqin Guan, Yutao |
author_sort | Zhang, Fubin |
collection | PubMed |
description | BACKGROUND: There has been lack of guidance for stratify treatment between cervical endometrioid adenocarcinoma (EC) and ordinary cervical adenocarcinoma (AC), therefore understanding the difference of prognosis between EC and AC is important for individualized therapy for these patients. METHODS: In this study, we compare the survival outcomes between cervical EC and AC patients from the SEER database. we analyzed 2,554 patients for overall survival (OS) and 2,527 patients for disease-specific survival (DSS), Cox regression and Kaplan-Meier analyses were conducted to analyze the survival outcomes of the AC and EC patients, a 1:1 propensity score matching (PSM) method was used to match patients and balance various factors, OS and DSS were analyzed among the subgroups before and after 1:1 PSM. RESULTS: In the unmatched cohort, in the multivariate analysis, no statistically significant difference was found in terms of OS (P=0.24) and DSS (P=0.20) between the EC and AC patients, The 3- and 5-year OS rates were 77.89% and 72.65% for the AC patients, and 83.38% and 75.64% for the EC patients respectively. The 3- and 5-year DSS rates were 84.93% and 79.69% for the EC patients, 83.97% and 76.78% for the AC patients, respectively. In the PSM cohort, 280 AC patients and 280 EC patients were included in the analysis of OS. 273 AC patients and 275 EC patients were included in the analysis of DSS, the Kaplan-Meier analysis and the multivariate analysis also produced similar results for the unmatched groups. CONCLUSIONS: There were no statistically significant differences in OS and DSS between the cervical EC and AC patients. |
format | Online Article Text |
id | pubmed-9273663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-92736632022-07-13 Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? Zhang, Fubin Jin, Bohong Yan, Hui Zhu, Tianhong Ding, Huiqing Chen, Xueqin Guan, Yutao Transl Cancer Res Original Article BACKGROUND: There has been lack of guidance for stratify treatment between cervical endometrioid adenocarcinoma (EC) and ordinary cervical adenocarcinoma (AC), therefore understanding the difference of prognosis between EC and AC is important for individualized therapy for these patients. METHODS: In this study, we compare the survival outcomes between cervical EC and AC patients from the SEER database. we analyzed 2,554 patients for overall survival (OS) and 2,527 patients for disease-specific survival (DSS), Cox regression and Kaplan-Meier analyses were conducted to analyze the survival outcomes of the AC and EC patients, a 1:1 propensity score matching (PSM) method was used to match patients and balance various factors, OS and DSS were analyzed among the subgroups before and after 1:1 PSM. RESULTS: In the unmatched cohort, in the multivariate analysis, no statistically significant difference was found in terms of OS (P=0.24) and DSS (P=0.20) between the EC and AC patients, The 3- and 5-year OS rates were 77.89% and 72.65% for the AC patients, and 83.38% and 75.64% for the EC patients respectively. The 3- and 5-year DSS rates were 84.93% and 79.69% for the EC patients, 83.97% and 76.78% for the AC patients, respectively. In the PSM cohort, 280 AC patients and 280 EC patients were included in the analysis of OS. 273 AC patients and 275 EC patients were included in the analysis of DSS, the Kaplan-Meier analysis and the multivariate analysis also produced similar results for the unmatched groups. CONCLUSIONS: There were no statistically significant differences in OS and DSS between the cervical EC and AC patients. AME Publishing Company 2022-06 /pmc/articles/PMC9273663/ /pubmed/35836529 http://dx.doi.org/10.21037/tcr-22-1180 Text en 2022 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Zhang, Fubin Jin, Bohong Yan, Hui Zhu, Tianhong Ding, Huiqing Chen, Xueqin Guan, Yutao Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? |
title | Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? |
title_full | Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? |
title_fullStr | Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? |
title_full_unstemmed | Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? |
title_short | Is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (SEER) database? |
title_sort | is there different prognosis between cervical endometrioid adenocarcinoma and ordinary cervical adenocarcinoma in a propensity score matching study based on the surveillance, epidemiology, and end results (seer) database? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273663/ https://www.ncbi.nlm.nih.gov/pubmed/35836529 http://dx.doi.org/10.21037/tcr-22-1180 |
work_keys_str_mv | AT zhangfubin istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase AT jinbohong istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase AT yanhui istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase AT zhutianhong istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase AT dinghuiqing istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase AT chenxueqin istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase AT guanyutao istheredifferentprognosisbetweencervicalendometrioidadenocarcinomaandordinarycervicaladenocarcinomainapropensityscorematchingstudybasedonthesurveillanceepidemiologyandendresultsseerdatabase |