Cargando…

Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature

Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Changhong, Ma, Yili, Wu, Dengqiang, Chen, Xiaoyu, Li, Chunjun, Chen, Jun, Zhou, Sufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273825/
https://www.ncbi.nlm.nih.gov/pubmed/35836959
http://dx.doi.org/10.3389/fmed.2022.833864
_version_ 1784745160956968960
author Wei, Changhong
Ma, Yili
Wu, Dengqiang
Chen, Xiaoyu
Li, Chunjun
Chen, Jun
Zhou, Sufang
author_facet Wei, Changhong
Ma, Yili
Wu, Dengqiang
Chen, Xiaoyu
Li, Chunjun
Chen, Jun
Zhou, Sufang
author_sort Wei, Changhong
collection PubMed
description Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition deteriorated. Enhanced CT showed that the right posterior upper chest wall mass invaded the adjacent bone, and the boundary between the lesion and the surrounding tissues was relatively clear. She then underwent posterior tumor removal surgery. The pathological examination confirmed the diagnosis of SEF. In histomorphology, the tumor displayed a typical epithelioid clear cell morphology, accompanied by extensive vitrification and fibrosis, which better helped to differentiate the tumor from low grade fibromyxoid sarcoma, solitary fibrous tumor and other entities. The immunohistochemical analysis showed a diffuse positive reaction to MUC4, a highly specific marker of SEF, which was detected by Immunohistochemistry (IHC), and fluorescence in-situ hybridization (FISH) confirmed that the EWSR1 gene was rearranged, while the FUS gene was not rearranged. This is the first time that we have encountered such this rare case and thus report this case with updated literature related to this tumor.
format Online
Article
Text
id pubmed-9273825
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92738252022-07-13 Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature Wei, Changhong Ma, Yili Wu, Dengqiang Chen, Xiaoyu Li, Chunjun Chen, Jun Zhou, Sufang Front Med (Lausanne) Medicine Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition deteriorated. Enhanced CT showed that the right posterior upper chest wall mass invaded the adjacent bone, and the boundary between the lesion and the surrounding tissues was relatively clear. She then underwent posterior tumor removal surgery. The pathological examination confirmed the diagnosis of SEF. In histomorphology, the tumor displayed a typical epithelioid clear cell morphology, accompanied by extensive vitrification and fibrosis, which better helped to differentiate the tumor from low grade fibromyxoid sarcoma, solitary fibrous tumor and other entities. The immunohistochemical analysis showed a diffuse positive reaction to MUC4, a highly specific marker of SEF, which was detected by Immunohistochemistry (IHC), and fluorescence in-situ hybridization (FISH) confirmed that the EWSR1 gene was rearranged, while the FUS gene was not rearranged. This is the first time that we have encountered such this rare case and thus report this case with updated literature related to this tumor. Frontiers Media S.A. 2022-06-28 /pmc/articles/PMC9273825/ /pubmed/35836959 http://dx.doi.org/10.3389/fmed.2022.833864 Text en Copyright © 2022 Wei, Ma, Wu, Chen, Li, Chen and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wei, Changhong
Ma, Yili
Wu, Dengqiang
Chen, Xiaoyu
Li, Chunjun
Chen, Jun
Zhou, Sufang
Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
title Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
title_full Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
title_fullStr Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
title_full_unstemmed Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
title_short Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
title_sort sclerosing epithelioid fibrosarcoma of the thoracic vertebrae: an fairly unusual case report with a short review of literature
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273825/
https://www.ncbi.nlm.nih.gov/pubmed/35836959
http://dx.doi.org/10.3389/fmed.2022.833864
work_keys_str_mv AT weichanghong sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature
AT mayili sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature
AT wudengqiang sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature
AT chenxiaoyu sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature
AT lichunjun sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature
AT chenjun sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature
AT zhousufang sclerosingepithelioidfibrosarcomaofthethoracicvertebraeanfairlyunusualcasereportwithashortreviewofliterature