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Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population

INTRODUCTION: Globally, women with dementia have a higher disease burden than men with dementia. In addition, women with diabetes especially are at higher risk for cognitive impairment and dementia compared to men with diabetes. Differences in the influence of diabetes on the cerebral vasculature an...

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Autores principales: Thomas, Elias G., Rhodius-Meester, Hanneke, Exalto, Lieza, Peters, Sanne A. E., van Bloemendaal, Liselotte, Ponds, Rudolf, Muller, Majon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273850/
https://www.ncbi.nlm.nih.gov/pubmed/35837485
http://dx.doi.org/10.3389/fnagi.2022.885787
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author Thomas, Elias G.
Rhodius-Meester, Hanneke
Exalto, Lieza
Peters, Sanne A. E.
van Bloemendaal, Liselotte
Ponds, Rudolf
Muller, Majon
author_facet Thomas, Elias G.
Rhodius-Meester, Hanneke
Exalto, Lieza
Peters, Sanne A. E.
van Bloemendaal, Liselotte
Ponds, Rudolf
Muller, Majon
author_sort Thomas, Elias G.
collection PubMed
description INTRODUCTION: Globally, women with dementia have a higher disease burden than men with dementia. In addition, women with diabetes especially are at higher risk for cognitive impairment and dementia compared to men with diabetes. Differences in the influence of diabetes on the cerebral vasculature and brain structure may contribute to these sex-specific differences. We examined sex-specific patterns in the relationship between diabetes and brain structure, as well as diabetes and cognitive function. METHODS: In total, 893 patients [age 79 ± 6.6 years, 446 (50%) women] from the Amsterdam Ageing Cohort with available data on brain structures (assessed by an MRI or CT scan) and cognitive function were included. All patients underwent a thorough standardized clinical and neuropsychological assessment (including tests on memory, executive functioning, processing speed, language). Brain structure abnormalities were quantified using visual scales. RESULTS: Cross-sectional multivariable regression analyses showed that diabetes was associated with increased incidence of cerebral lacunes and brain atrophy in women (OR 2.18 (1.00–4.72) but not in men. Furthermore, diabetes was associated with decreased executive function, processing speed and language in women [B −0.07 (0.00–0.13), −0.06 (0.02–0.10) and −0.07 (0.01–0.12) resp.] but not in men. CONCLUSIONS: Diabetes is related to increased risk of having lacunes, brain atrophy and impaired cognitive function in women but not in men. Further research is required to understand the time trajectory leading up to these changes and to understand the mechanisms behind them in order to improve preventive health care for both sexes.
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spelling pubmed-92738502022-07-13 Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population Thomas, Elias G. Rhodius-Meester, Hanneke Exalto, Lieza Peters, Sanne A. E. van Bloemendaal, Liselotte Ponds, Rudolf Muller, Majon Front Aging Neurosci Aging Neuroscience INTRODUCTION: Globally, women with dementia have a higher disease burden than men with dementia. In addition, women with diabetes especially are at higher risk for cognitive impairment and dementia compared to men with diabetes. Differences in the influence of diabetes on the cerebral vasculature and brain structure may contribute to these sex-specific differences. We examined sex-specific patterns in the relationship between diabetes and brain structure, as well as diabetes and cognitive function. METHODS: In total, 893 patients [age 79 ± 6.6 years, 446 (50%) women] from the Amsterdam Ageing Cohort with available data on brain structures (assessed by an MRI or CT scan) and cognitive function were included. All patients underwent a thorough standardized clinical and neuropsychological assessment (including tests on memory, executive functioning, processing speed, language). Brain structure abnormalities were quantified using visual scales. RESULTS: Cross-sectional multivariable regression analyses showed that diabetes was associated with increased incidence of cerebral lacunes and brain atrophy in women (OR 2.18 (1.00–4.72) but not in men. Furthermore, diabetes was associated with decreased executive function, processing speed and language in women [B −0.07 (0.00–0.13), −0.06 (0.02–0.10) and −0.07 (0.01–0.12) resp.] but not in men. CONCLUSIONS: Diabetes is related to increased risk of having lacunes, brain atrophy and impaired cognitive function in women but not in men. Further research is required to understand the time trajectory leading up to these changes and to understand the mechanisms behind them in order to improve preventive health care for both sexes. Frontiers Media S.A. 2022-06-28 /pmc/articles/PMC9273850/ /pubmed/35837485 http://dx.doi.org/10.3389/fnagi.2022.885787 Text en Copyright © 2022 Thomas, Rhodius-Meester, Exalto, Peters, van Bloemendaal, Ponds and Muller. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Thomas, Elias G.
Rhodius-Meester, Hanneke
Exalto, Lieza
Peters, Sanne A. E.
van Bloemendaal, Liselotte
Ponds, Rudolf
Muller, Majon
Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
title Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
title_full Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
title_fullStr Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
title_full_unstemmed Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
title_short Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
title_sort sex-specific associations of diabetes with brain structure and function in a geriatric population
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273850/
https://www.ncbi.nlm.nih.gov/pubmed/35837485
http://dx.doi.org/10.3389/fnagi.2022.885787
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