Spatiotemporal Patterns of Substance P-Bound MRGPRX2 Reveal a Novel Connection Between Macropinosome Resolution and Secretory Granule Regeneration in Mast Cells

MRGPRX2, the human member of the MAS-related G protein coupled receptors (Mrgprs), serves as the cellular target of human mast cells (MCs) for innate ligands, including neuropeptides and antimicrobial peptides. In addition, MRGPRX2 also functions as the receptor for multiple FDA-approved drugs. As s...

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Detalles Bibliográficos
Autores principales: Lazki-Hagenbach, Pia, Kleeblatt, Elisabeth, Ali, Hydar, Sagi-Eisenberg, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273857/
https://www.ncbi.nlm.nih.gov/pubmed/35837385
http://dx.doi.org/10.3389/fimmu.2022.892239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273857/
https://www.ncbi.nlm.nih.gov/pubmed/35837385
http://dx.doi.org/10.3389/fimmu.2022.892239

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