Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla

The sensory experience of pain depends not only on the transmission of noxious information (nociception), but on the state of the body in a biological, psychological, and social milieu. A brainstem pain-modulating system with its output node in the rostral ventromedial medulla (RVM) can regulate the...

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Autores principales: Chen, Qiliang, Heinricher, Mary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pain Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274196/
https://www.ncbi.nlm.nih.gov/pubmed/35836737
http://dx.doi.org/10.3389/fpain.2022.932476
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author Chen, Qiliang
Heinricher, Mary M.
author_facet Chen, Qiliang
Heinricher, Mary M.
author_sort Chen, Qiliang
collection PubMed
description The sensory experience of pain depends not only on the transmission of noxious information (nociception), but on the state of the body in a biological, psychological, and social milieu. A brainstem pain-modulating system with its output node in the rostral ventromedial medulla (RVM) can regulate the threshold and gain for nociceptive transmission. This review considers the current understanding of how RVM pain-modulating neurons, namely ON-cells and OFF-cells, are engaged by “top-down” cognitive and emotional factors, as well as by “bottom-up” sensory inputs, to enhance or suppress pain.
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spelling pubmed-92741962022-07-13 Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla Chen, Qiliang Heinricher, Mary M. Front Pain Res (Lausanne) Pain Research The sensory experience of pain depends not only on the transmission of noxious information (nociception), but on the state of the body in a biological, psychological, and social milieu. A brainstem pain-modulating system with its output node in the rostral ventromedial medulla (RVM) can regulate the threshold and gain for nociceptive transmission. This review considers the current understanding of how RVM pain-modulating neurons, namely ON-cells and OFF-cells, are engaged by “top-down” cognitive and emotional factors, as well as by “bottom-up” sensory inputs, to enhance or suppress pain. Frontiers Media S.A. 2022-06-28 /pmc/articles/PMC9274196/ /pubmed/35836737 http://dx.doi.org/10.3389/fpain.2022.932476 Text en Copyright © 2022 Chen and Heinricher. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Chen, Qiliang
Heinricher, Mary M.
Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
title Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
title_full Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
title_fullStr Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
title_full_unstemmed Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
title_short Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
title_sort shifting the balance: how top-down and bottom-up input modulate pain via the rostral ventromedial medulla
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274196/
https://www.ncbi.nlm.nih.gov/pubmed/35836737
http://dx.doi.org/10.3389/fpain.2022.932476
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