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Association of HLA-DQ Heterodimer Residues −18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial–Type 1

OBJECTIVE: The purpose was to test the hypothesis that the HLA-DQαβ heterodimer structure is related to the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Next-generation targeted sequencing was used to genotype HLA-DQA1-B1 clas...

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Detalles Bibliográficos
Autores principales:	Zhao, Lue Ping, Skyler, Jay, Papadopoulos, George K., Pugliese, Alberto, Najera, James Antonio, Bondinas, George P., Moustakas, Antonis K., Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Lernmark, Åke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2022
Materias:	Pathophysiology/Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274226/ https://www.ncbi.nlm.nih.gov/pubmed/35621697 http://dx.doi.org/10.2337/dc21-1628

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