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Gut microbiome in gastrointestinal cancer: a friend or foe?

The impact of the gut microbiome on host health is becoming increasingly recognized. To date, there is growing evidence that the complex characteristics of the microbial community play key roles as potential biomarkers and predictors of responses in cancer therapy. Many studies have shown that alter...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Baba, Yoshifumi, Ishimoto, Takatsugu, Gu, Xi, Zhang, Jun, Nomoto, Daichi, Okadome, Kazuo, Baba, Hideo, Qiu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274484/
https://www.ncbi.nlm.nih.gov/pubmed/35844804
http://dx.doi.org/10.7150/ijbs.69331
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author Liu, Yang
Baba, Yoshifumi
Ishimoto, Takatsugu
Gu, Xi
Zhang, Jun
Nomoto, Daichi
Okadome, Kazuo
Baba, Hideo
Qiu, Peng
author_facet Liu, Yang
Baba, Yoshifumi
Ishimoto, Takatsugu
Gu, Xi
Zhang, Jun
Nomoto, Daichi
Okadome, Kazuo
Baba, Hideo
Qiu, Peng
author_sort Liu, Yang
collection PubMed
description The impact of the gut microbiome on host health is becoming increasingly recognized. To date, there is growing evidence that the complex characteristics of the microbial community play key roles as potential biomarkers and predictors of responses in cancer therapy. Many studies have shown that altered commensal bacteria lead to cancer susceptibility and progression in diverse pathways. In this review, we critically assess the data for gut microbiota related to gastrointestinal cancer, including esophageal, gastric, pancreatic, colorectal cancer, hepatocellular carcinoma and cholangiocarcinoma. Importantly, the underlying mechanisms of gut microbiota involved in cancer occurrence, prevention and treatment are elucidated. The purpose of this review is to provide novel insights for applying this understanding to the development of new therapeutic strategies in gastrointestinal cancer by targeting the microbial community.
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spelling pubmed-92744842022-07-15 Gut microbiome in gastrointestinal cancer: a friend or foe? Liu, Yang Baba, Yoshifumi Ishimoto, Takatsugu Gu, Xi Zhang, Jun Nomoto, Daichi Okadome, Kazuo Baba, Hideo Qiu, Peng Int J Biol Sci Review The impact of the gut microbiome on host health is becoming increasingly recognized. To date, there is growing evidence that the complex characteristics of the microbial community play key roles as potential biomarkers and predictors of responses in cancer therapy. Many studies have shown that altered commensal bacteria lead to cancer susceptibility and progression in diverse pathways. In this review, we critically assess the data for gut microbiota related to gastrointestinal cancer, including esophageal, gastric, pancreatic, colorectal cancer, hepatocellular carcinoma and cholangiocarcinoma. Importantly, the underlying mechanisms of gut microbiota involved in cancer occurrence, prevention and treatment are elucidated. The purpose of this review is to provide novel insights for applying this understanding to the development of new therapeutic strategies in gastrointestinal cancer by targeting the microbial community. Ivyspring International Publisher 2022-06-21 /pmc/articles/PMC9274484/ /pubmed/35844804 http://dx.doi.org/10.7150/ijbs.69331 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Liu, Yang
Baba, Yoshifumi
Ishimoto, Takatsugu
Gu, Xi
Zhang, Jun
Nomoto, Daichi
Okadome, Kazuo
Baba, Hideo
Qiu, Peng
Gut microbiome in gastrointestinal cancer: a friend or foe?
title Gut microbiome in gastrointestinal cancer: a friend or foe?
title_full Gut microbiome in gastrointestinal cancer: a friend or foe?
title_fullStr Gut microbiome in gastrointestinal cancer: a friend or foe?
title_full_unstemmed Gut microbiome in gastrointestinal cancer: a friend or foe?
title_short Gut microbiome in gastrointestinal cancer: a friend or foe?
title_sort gut microbiome in gastrointestinal cancer: a friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274484/
https://www.ncbi.nlm.nih.gov/pubmed/35844804
http://dx.doi.org/10.7150/ijbs.69331
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