Cargando…

Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling

High frequent metastasis is the major cause of breast cancer (BC) mortality among women. However, the molecular mechanisms underlying BC metastasis remain largely unknown. Here, we identified six hub BC metastasis driver genes (BEND5, HSD11B1, NEDD9, SAA2, SH2D2A and TNFSF4) through bioinformatics a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Yanzhu, Zhang, Deyu, Chen, Jingyi, Jiang, Qiwei, Song, Songze, Mi, Yue, Wang, Tao, Ye, Qinong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274485/ https://www.ncbi.nlm.nih.gov/pubmed/35844785 http://dx.doi.org/10.7150/ijbs.70866

Ejemplares similares

RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway
por: Zhang, Deyu, et al.
Publicado: (2021)

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9
por: Chen, Shan, et al.
Publicado: (2013)

Loss of the Notch effector RBPJ promotes tumorigenesis
por: Kulic, Iva, et al.
Publicado: (2015)

Notch-independent RBPJ controls angiogenesis in the adult heart
por: Díaz-Trelles, Ramón, et al.
Publicado: (2016)

Notch-dependent and -independent functions of transcription factor RBPJ
por: Friedrich, Tobias, et al.
Publicado: (2022)

CHMP4A stimulates CD8+ T‐lymphocyte infiltration and inhibits breast tumor growth via the LSD1/IFNβ axis
por: Song, Songze, et al.
Publicado: (2023)

Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function
por: Salguero-Jiménez, Alejandro, et al.
Publicado: (2018)

Neural crest Notch/Rbpj signaling regulates olfactory gliogenesis and neuronal migration
por: Miller, Sophie R., et al.
Publicado: (2018)

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ
por: Hurtado, Cecilia, et al.
Publicado: (2019)

Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice
por: Nielsen, Corinne M., et al.
Publicado: (2022)

RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors
por: Chen, Edward L. Y., et al.
Publicado: (2019)

Notch-RBPJ Pathway for the Differentiation of Bone Marrow Mesenchymal Stem Cells in Femoral Head Necrosis
por: Liu, Kangping, et al.
Publicado: (2023)

Identification of Potential RBPJ-Specific Inhibitors for Blocking Notch Signaling in Breast Cancer Using a Drug Repurposing Strategy
por: Rui, Mengjie, et al.
Publicado: (2022)

An RBPJ-Drosophila Model Reveals Dependence of RBPJ Protein Stability on the Formation of Transcription–Regulator Complexes
por: Gahr, Bernd M., et al.
Publicado: (2019)

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
por: Jiang, Hua, et al.
Publicado: (2022)

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms
por: Zhang, Shuang, et al.
Publicado: (2014)

RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy
por: Nagao, Hiroko, et al.
Publicado: (2012)

RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking
por: Lake, Robert J., et al.
Publicado: (2014)

The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3
por: Hall, Daniel, et al.
Publicado: (2022)

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1
por: Xu, Tao, et al.
Publicado: (2017)

Correction: RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking
Publicado: (2016)

The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis
por: Raafat, Ahmed, et al.
Publicado: (2017)

HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner
por: Dreval, Kostiantyn, et al.
Publicado: (2019)

Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma
por: Zhang, Deyu, et al.
Publicado: (2020)

Deficiency of Rbpj Leads to Defective Stress-Induced Hematopoietic Stem Cell Functions and Hif Mediated Activation of Non-canonical Notch Signaling Pathways
por: Lakhan, Ram, et al.
Publicado: (2021)

MiR-3180 inhibits hepatocellular carcinoma growth and metastasis by targeting lipid synthesis and uptake
por: Hong, Jie, et al.
Publicado: (2023)

The role of the transcription factor Rbpj in the development of dorsal root ganglia
por: Hu, Ze-Lan, et al.
Publicado: (2011)

A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein
por: Li, Pengyun, et al.
Publicado: (2021)

Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina
por: Miesfeld, Joel B., et al.
Publicado: (2018)

Rbpj expression in regulatory T cells is critical for restraining T(H)2 responses
por: Delacher, Michael, et al.
Publicado: (2019)

RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ
por: Tang, Huancheng, et al.
Publicado: (2022)

Spatiotemporal coordination of trophoblast and allantoic Rbpj signaling directs normal placental morphogenesis
por: Lu, Jinhua, et al.
Publicado: (2019)

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
por: Diéguez-Hurtado, Rodrigo, et al.
Publicado: (2019)

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ
por: Webb, Louise M. C., et al.
Publicado: (2021)

Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8(+) T cells in hepatocellular carcinoma
por: Pan, Banglun, et al.
Publicado: (2023)

A gene regulation network controlled by Celf1 protein–rbpj mRNA interaction in Xenopus somite segmentation
por: Cibois, Marie, et al.
Publicado: (2013)

Oridonin Inhibits Tumor Growth and Metastasis through Anti-Angiogenesis by Blocking the Notch Signaling
por: Dong, Yanmin, et al.
Publicado: (2014)

Abrogation of Rbpj Attenuates Experimental Autoimmune Uveoretinitis by Inhibiting IL-22-Producing CD4(+) T Cells
por: Bhuyan, Zaied Ahmed, et al.
Publicado: (2014)

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion
por: Tharehalli, Umesh, et al.
Publicado: (2018)

Inhibition of notch promotes liver metastasis
por: Banerjee, Debarshi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tq8clqk3u252vg5o579kjm7m9j