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The emerging role of LRRK2 in tauopathies
Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse patholog...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274527/ https://www.ncbi.nlm.nih.gov/pubmed/35815712 http://dx.doi.org/10.1042/CS20220067 |
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author | Herbst, Susanne Lewis, Patrick A. Morris, Huw R. |
author_facet | Herbst, Susanne Lewis, Patrick A. Morris, Huw R. |
author_sort | Herbst, Susanne |
collection | PubMed |
description | Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson’s syndrome including tau pathology resembling progressive supranuclear palsy (PSP). The recent discovery that variation at the LRRK2 locus is associated with the progression of PSP highlights the potential importance of LRRK2 in tauopathies. Here, we review the emerging evidence and discuss the potential impact of LRRK2 dysfunction on tau aggregation, lysosomal function, and endocytosis and exocytosis. |
format | Online Article Text |
id | pubmed-9274527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92745272022-07-21 The emerging role of LRRK2 in tauopathies Herbst, Susanne Lewis, Patrick A. Morris, Huw R. Clin Sci (Lond) Cell Homeostasis & Autophagy Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson’s syndrome including tau pathology resembling progressive supranuclear palsy (PSP). The recent discovery that variation at the LRRK2 locus is associated with the progression of PSP highlights the potential importance of LRRK2 in tauopathies. Here, we review the emerging evidence and discuss the potential impact of LRRK2 dysfunction on tau aggregation, lysosomal function, and endocytosis and exocytosis. Portland Press Ltd. 2022-07 2022-07-11 /pmc/articles/PMC9274527/ /pubmed/35815712 http://dx.doi.org/10.1042/CS20220067 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for the present article was enabled by the participation of University College London in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. |
spellingShingle | Cell Homeostasis & Autophagy Herbst, Susanne Lewis, Patrick A. Morris, Huw R. The emerging role of LRRK2 in tauopathies |
title | The emerging role of LRRK2 in tauopathies |
title_full | The emerging role of LRRK2 in tauopathies |
title_fullStr | The emerging role of LRRK2 in tauopathies |
title_full_unstemmed | The emerging role of LRRK2 in tauopathies |
title_short | The emerging role of LRRK2 in tauopathies |
title_sort | emerging role of lrrk2 in tauopathies |
topic | Cell Homeostasis & Autophagy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274527/ https://www.ncbi.nlm.nih.gov/pubmed/35815712 http://dx.doi.org/10.1042/CS20220067 |
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