Cargando…

The emerging role of LRRK2 in tauopathies

Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse patholog...

Descripción completa

Detalles Bibliográficos
Autores principales: Herbst, Susanne, Lewis, Patrick A., Morris, Huw R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274527/
https://www.ncbi.nlm.nih.gov/pubmed/35815712
http://dx.doi.org/10.1042/CS20220067
_version_ 1784745322810966016
author Herbst, Susanne
Lewis, Patrick A.
Morris, Huw R.
author_facet Herbst, Susanne
Lewis, Patrick A.
Morris, Huw R.
author_sort Herbst, Susanne
collection PubMed
description Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson’s syndrome including tau pathology resembling progressive supranuclear palsy (PSP). The recent discovery that variation at the LRRK2 locus is associated with the progression of PSP highlights the potential importance of LRRK2 in tauopathies. Here, we review the emerging evidence and discuss the potential impact of LRRK2 dysfunction on tau aggregation, lysosomal function, and endocytosis and exocytosis.
format Online
Article
Text
id pubmed-9274527
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-92745272022-07-21 The emerging role of LRRK2 in tauopathies Herbst, Susanne Lewis, Patrick A. Morris, Huw R. Clin Sci (Lond) Cell Homeostasis & Autophagy Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson’s syndrome including tau pathology resembling progressive supranuclear palsy (PSP). The recent discovery that variation at the LRRK2 locus is associated with the progression of PSP highlights the potential importance of LRRK2 in tauopathies. Here, we review the emerging evidence and discuss the potential impact of LRRK2 dysfunction on tau aggregation, lysosomal function, and endocytosis and exocytosis. Portland Press Ltd. 2022-07 2022-07-11 /pmc/articles/PMC9274527/ /pubmed/35815712 http://dx.doi.org/10.1042/CS20220067 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for the present article was enabled by the participation of University College London in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Cell Homeostasis & Autophagy
Herbst, Susanne
Lewis, Patrick A.
Morris, Huw R.
The emerging role of LRRK2 in tauopathies
title The emerging role of LRRK2 in tauopathies
title_full The emerging role of LRRK2 in tauopathies
title_fullStr The emerging role of LRRK2 in tauopathies
title_full_unstemmed The emerging role of LRRK2 in tauopathies
title_short The emerging role of LRRK2 in tauopathies
title_sort emerging role of lrrk2 in tauopathies
topic Cell Homeostasis & Autophagy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274527/
https://www.ncbi.nlm.nih.gov/pubmed/35815712
http://dx.doi.org/10.1042/CS20220067
work_keys_str_mv AT herbstsusanne theemergingroleoflrrk2intauopathies
AT lewispatricka theemergingroleoflrrk2intauopathies
AT morrishuwr theemergingroleoflrrk2intauopathies
AT herbstsusanne emergingroleoflrrk2intauopathies
AT lewispatricka emergingroleoflrrk2intauopathies
AT morrishuwr emergingroleoflrrk2intauopathies