SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways

Background: Given the importance of microvascular injury in infarct formation and expansion, development of therapeutic strategies for microvascular protection against myocardial ischemia/reperfusion injury (IRI) is of great interest. Here, we explored the molecular mechanisms underlying the protect...

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Detalles Bibliográficos
Autores principales: Ma, Li, Zou, Rongjun, Shi, Wanting, Zhou, Na, Chen, Shaoxian, Zhou, Hao, Chen, Xinxin, Wu, Yueheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274739/
https://www.ncbi.nlm.nih.gov/pubmed/35836807
http://dx.doi.org/10.7150/thno.75121

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