KDM4 inhibitor SD49-7 attenuates leukemia stem cell via KDM4A/MDM2/p21(CIP1) axis

Rationale: Traditional treatments for leukemia fail to address stem cell drug resistance characterized by epigenetic mediators such as histone lysine-specific demethylase 4 (KDM4). The KDM4 family, which acts as epigenetic regulators inducing histone demethylation during the development and progress...

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Detalles Bibliográficos
Autores principales: Li, Yinghui, Wang, Chaoqun, Gao, Huier, Gu, Jiali, Zhang, Yiran, Zhang, Yingyi, Xie, Min, Cheng, Xuelian, Yang, Ming, Zhang, Wenshan, Li, Yafang, He, Mei, Xu, Hui, Zhang, Hexiao, Ji, Qing, Ma, Tianhua, Ding, Sheng, Zhao, Yu, Gao, Yingdai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274755/
https://www.ncbi.nlm.nih.gov/pubmed/35836814
http://dx.doi.org/10.7150/thno.71460

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