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Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology
INTRODUCTION: The impact of hepatorenal function on plasma biomarkers of neuropathology is unknown. Herein, we measured several plasma biomarkers in patients with cirrhosis. METHODS: Plasma phosphorylated tau (p‐tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274803/ https://www.ncbi.nlm.nih.gov/pubmed/35845260 http://dx.doi.org/10.1002/dad2.12321 |
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author | Berry, Kacey Asken, Breton M. Grab, Joshua D. Chan, Brandon Lario Lago, Argentina Wong, Randi Seetharaman, Srilakshmi LaHue, Sara C. Possin, Katherine L. Rojas, Julio C. Kramer, Joel H. Boxer, Adam L. Lai, Jennifer C. VandeVrede, Lawren |
author_facet | Berry, Kacey Asken, Breton M. Grab, Joshua D. Chan, Brandon Lario Lago, Argentina Wong, Randi Seetharaman, Srilakshmi LaHue, Sara C. Possin, Katherine L. Rojas, Julio C. Kramer, Joel H. Boxer, Adam L. Lai, Jennifer C. VandeVrede, Lawren |
author_sort | Berry, Kacey |
collection | PubMed |
description | INTRODUCTION: The impact of hepatorenal function on plasma biomarkers of neuropathology is unknown. Herein, we measured several plasma biomarkers in patients with cirrhosis. METHODS: Plasma phosphorylated tau (p‐tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tau (t‐tau), and ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) were measured in 135 adults with cirrhosis and 22 healthy controls using Simoa. Within cirrhosis, associations between biomarkers and hepatorenal function were explored using linear regression. RESULTS: p‐tau181, NfL, t‐tau, and UCHL1 were increased 2‐ to 4‐fold in cirrhosis, whereas GFAP was not increased. Within cirrhosis, creatinine moderately correlated with p‐tau181 (β = 0.75, P < .01), NfL (β = 0.32, P < .01), and t‐tau (β = 0.31, P < .01), but not GFAP (β = –0.01, P = .88) or UCHL1 (β = –0.05, P = .60), whereas albumin showed weak, inverse correlations: p‐tau181 (β = –0.18, P < .01), NfL (β = –0.22, P < .01), GFAP (β = –0.17, P < .05), t‐tau (β = –0.20, P = .02), and UCHL1 (β = –0.15, P = .09). CONCLUSIONS: Elevated p‐tau181, NfL, and t‐tau in cirrhosis were associated with renal impairment and hypoalbuminemia, suggesting that hepatorenal function may be important when interpreting plasma biomarkers of neuropathology. |
format | Online Article Text |
id | pubmed-9274803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92748032022-07-15 Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology Berry, Kacey Asken, Breton M. Grab, Joshua D. Chan, Brandon Lario Lago, Argentina Wong, Randi Seetharaman, Srilakshmi LaHue, Sara C. Possin, Katherine L. Rojas, Julio C. Kramer, Joel H. Boxer, Adam L. Lai, Jennifer C. VandeVrede, Lawren Alzheimers Dement (Amst) Fluid Biomarkers INTRODUCTION: The impact of hepatorenal function on plasma biomarkers of neuropathology is unknown. Herein, we measured several plasma biomarkers in patients with cirrhosis. METHODS: Plasma phosphorylated tau (p‐tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tau (t‐tau), and ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) were measured in 135 adults with cirrhosis and 22 healthy controls using Simoa. Within cirrhosis, associations between biomarkers and hepatorenal function were explored using linear regression. RESULTS: p‐tau181, NfL, t‐tau, and UCHL1 were increased 2‐ to 4‐fold in cirrhosis, whereas GFAP was not increased. Within cirrhosis, creatinine moderately correlated with p‐tau181 (β = 0.75, P < .01), NfL (β = 0.32, P < .01), and t‐tau (β = 0.31, P < .01), but not GFAP (β = –0.01, P = .88) or UCHL1 (β = –0.05, P = .60), whereas albumin showed weak, inverse correlations: p‐tau181 (β = –0.18, P < .01), NfL (β = –0.22, P < .01), GFAP (β = –0.17, P < .05), t‐tau (β = –0.20, P = .02), and UCHL1 (β = –0.15, P = .09). CONCLUSIONS: Elevated p‐tau181, NfL, and t‐tau in cirrhosis were associated with renal impairment and hypoalbuminemia, suggesting that hepatorenal function may be important when interpreting plasma biomarkers of neuropathology. John Wiley and Sons Inc. 2022-07-12 /pmc/articles/PMC9274803/ /pubmed/35845260 http://dx.doi.org/10.1002/dad2.12321 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Fluid Biomarkers Berry, Kacey Asken, Breton M. Grab, Joshua D. Chan, Brandon Lario Lago, Argentina Wong, Randi Seetharaman, Srilakshmi LaHue, Sara C. Possin, Katherine L. Rojas, Julio C. Kramer, Joel H. Boxer, Adam L. Lai, Jennifer C. VandeVrede, Lawren Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
title | Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
title_full | Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
title_fullStr | Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
title_full_unstemmed | Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
title_short | Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
title_sort | hepatic and renal function impact concentrations of plasma biomarkers of neuropathology |
topic | Fluid Biomarkers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274803/ https://www.ncbi.nlm.nih.gov/pubmed/35845260 http://dx.doi.org/10.1002/dad2.12321 |
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