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Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study

Evidence about the association of bullous pemphigoid and the risk of cancer is conflicting. Patients diagnosed with bullous pemphigoid (n = 5,739) between 2005 and 2016 were matched with a control cohort from the general population (n = 17,168) to estimate their over-all and specific risk of cancer....

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Autores principales: ALBADRI, Zeyad, THORSLUND, Kristofer, HÄBEL, Henrike, SEIFERT, Oliver, GRÖNHAGEN, Carina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274914/
https://www.ncbi.nlm.nih.gov/pubmed/32852559
http://dx.doi.org/10.2340/00015555-3622
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author ALBADRI, Zeyad
THORSLUND, Kristofer
HÄBEL, Henrike
SEIFERT, Oliver
GRÖNHAGEN, Carina
author_facet ALBADRI, Zeyad
THORSLUND, Kristofer
HÄBEL, Henrike
SEIFERT, Oliver
GRÖNHAGEN, Carina
author_sort ALBADRI, Zeyad
collection PubMed
description Evidence about the association of bullous pemphigoid and the risk of cancer is conflicting. Patients diagnosed with bullous pemphigoid (n = 5,739) between 2005 and 2016 were matched with a control cohort from the general population (n = 17,168) to estimate their over-all and specific risk of cancer. The risk of squamous cell cancer of the skin (cSCC) was increased in patients with bullous pemphigoid (hazard ratio (HR) 1.3; 95% confidence interval (CI) 1.1–1.6). The risk of lymphoma within one year after bullous pemphigoid diagnosis was also increased (HR 3.1; 95% CI 1.3–7.6). While overall cancer risk prior to diagnosis of bullous pemphigoid was similar in cases and controls (prevalence odds ratio (POR) 1.0; 95% CI 0.9–1.0), the risk of male genital cancer within one year prior to diagnosis of bullous pemphigoid was lower in cases (POR 0.4; 95% CI 0.2–0.8). Clinicians must be aware of the increased risk of cSCC and lymphoma in patients with bullous pemphigoid.
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spelling pubmed-92749142022-10-20 Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study ALBADRI, Zeyad THORSLUND, Kristofer HÄBEL, Henrike SEIFERT, Oliver GRÖNHAGEN, Carina Acta Derm Venereol Investigative Report Evidence about the association of bullous pemphigoid and the risk of cancer is conflicting. Patients diagnosed with bullous pemphigoid (n = 5,739) between 2005 and 2016 were matched with a control cohort from the general population (n = 17,168) to estimate their over-all and specific risk of cancer. The risk of squamous cell cancer of the skin (cSCC) was increased in patients with bullous pemphigoid (hazard ratio (HR) 1.3; 95% confidence interval (CI) 1.1–1.6). The risk of lymphoma within one year after bullous pemphigoid diagnosis was also increased (HR 3.1; 95% CI 1.3–7.6). While overall cancer risk prior to diagnosis of bullous pemphigoid was similar in cases and controls (prevalence odds ratio (POR) 1.0; 95% CI 0.9–1.0), the risk of male genital cancer within one year prior to diagnosis of bullous pemphigoid was lower in cases (POR 0.4; 95% CI 0.2–0.8). Clinicians must be aware of the increased risk of cSCC and lymphoma in patients with bullous pemphigoid. Society for Publication of Acta Dermato-Venereologica 2020-10-14 /pmc/articles/PMC9274914/ /pubmed/32852559 http://dx.doi.org/10.2340/00015555-3622 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Investigative Report
ALBADRI, Zeyad
THORSLUND, Kristofer
HÄBEL, Henrike
SEIFERT, Oliver
GRÖNHAGEN, Carina
Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
title Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
title_full Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
title_fullStr Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
title_full_unstemmed Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
title_short Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
title_sort increased risk of squamous cell carcinoma of the skin and lymphoma among 5,739 patients with bullous pemphigoid: a swedish nationwide cohort study
topic Investigative Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274914/
https://www.ncbi.nlm.nih.gov/pubmed/32852559
http://dx.doi.org/10.2340/00015555-3622
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