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Sex Differences in the Alcohol-Mediated Modulation of BLA Network States
Alcohol use, reported by 85% of adults in the United States, is highly comorbid with mood disorders, like generalized anxiety disorder and major depression. The basolateral amygdala (BLA) is an area of the brain that is heavily implicated in both mood disorders and alcohol use disorder. Importantly,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275151/ https://www.ncbi.nlm.nih.gov/pubmed/35788104 http://dx.doi.org/10.1523/ENEURO.0010-22.2022 |
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author | DiLeo, Alyssa Antonoudiou, Pantelis Ha, Spencer Maguire, Jamie L. |
author_facet | DiLeo, Alyssa Antonoudiou, Pantelis Ha, Spencer Maguire, Jamie L. |
author_sort | DiLeo, Alyssa |
collection | PubMed |
description | Alcohol use, reported by 85% of adults in the United States, is highly comorbid with mood disorders, like generalized anxiety disorder and major depression. The basolateral amygdala (BLA) is an area of the brain that is heavily implicated in both mood disorders and alcohol use disorder. Importantly, the modulation of BLA network/oscillatory states via parvalbumin (PV)-positive GABAergic interneurons has been shown to control the behavioral expression of fear and anxiety. Further, PV interneurons express a high density of δ subunit-containing GABA(A) receptors (GABA(A)Rs), which are sensitive to low concentrations of alcohol. Therefore, we hypothesized that the effects of alcohol may modulate BLA network states that have been associated with fear and anxiety behaviors via δ-GABA(A)Rs on PV interneurons in the BLA. Given the impact of ovarian hormones on the expression of δ-GABA(A)Rs, we also examined the ability of alcohol to modulate local field potentials in the BLA from male and female C57BL/6J and Gabrd(−/−) mice after acute and repeated exposure to alcohol. Here, we demonstrate that acute and repeated alcohol can differentially modulate oscillatory states in male and female C57BL/6J mice, a process that involves δ-GABA(A)Rs. This is the first study to demonstrate that alcohol is capable of altering network states implicated in both anxiety and alcohol use disorders. |
format | Online Article Text |
id | pubmed-9275151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-92751512022-07-13 Sex Differences in the Alcohol-Mediated Modulation of BLA Network States DiLeo, Alyssa Antonoudiou, Pantelis Ha, Spencer Maguire, Jamie L. eNeuro Research Article: New Research Alcohol use, reported by 85% of adults in the United States, is highly comorbid with mood disorders, like generalized anxiety disorder and major depression. The basolateral amygdala (BLA) is an area of the brain that is heavily implicated in both mood disorders and alcohol use disorder. Importantly, the modulation of BLA network/oscillatory states via parvalbumin (PV)-positive GABAergic interneurons has been shown to control the behavioral expression of fear and anxiety. Further, PV interneurons express a high density of δ subunit-containing GABA(A) receptors (GABA(A)Rs), which are sensitive to low concentrations of alcohol. Therefore, we hypothesized that the effects of alcohol may modulate BLA network states that have been associated with fear and anxiety behaviors via δ-GABA(A)Rs on PV interneurons in the BLA. Given the impact of ovarian hormones on the expression of δ-GABA(A)Rs, we also examined the ability of alcohol to modulate local field potentials in the BLA from male and female C57BL/6J and Gabrd(−/−) mice after acute and repeated exposure to alcohol. Here, we demonstrate that acute and repeated alcohol can differentially modulate oscillatory states in male and female C57BL/6J mice, a process that involves δ-GABA(A)Rs. This is the first study to demonstrate that alcohol is capable of altering network states implicated in both anxiety and alcohol use disorders. Society for Neuroscience 2022-07-07 /pmc/articles/PMC9275151/ /pubmed/35788104 http://dx.doi.org/10.1523/ENEURO.0010-22.2022 Text en Copyright © 2022 DiLeo et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: New Research DiLeo, Alyssa Antonoudiou, Pantelis Ha, Spencer Maguire, Jamie L. Sex Differences in the Alcohol-Mediated Modulation of BLA Network States |
title | Sex Differences in the Alcohol-Mediated Modulation of BLA Network States |
title_full | Sex Differences in the Alcohol-Mediated Modulation of BLA Network States |
title_fullStr | Sex Differences in the Alcohol-Mediated Modulation of BLA Network States |
title_full_unstemmed | Sex Differences in the Alcohol-Mediated Modulation of BLA Network States |
title_short | Sex Differences in the Alcohol-Mediated Modulation of BLA Network States |
title_sort | sex differences in the alcohol-mediated modulation of bla network states |
topic | Research Article: New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275151/ https://www.ncbi.nlm.nih.gov/pubmed/35788104 http://dx.doi.org/10.1523/ENEURO.0010-22.2022 |
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