Cargando…
Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study
BACKGROUND: Although the characteristics of intracranial aneurysms (IAs) in different age groups have been well documented, they remain relatively unclear in elderly patients due to a lack of large sample studies. METHODS: Data from IA patients aged more than 70 years who were treated in our centre...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275156/ https://www.ncbi.nlm.nih.gov/pubmed/35820817 http://dx.doi.org/10.1186/s12883-022-02786-z |
_version_ | 1784745433957924864 |
---|---|
author | Chen, Ruiqi Wen, Dingke Xiao, Anqi Guo, Rui You, Chao Liu, Yi |
author_facet | Chen, Ruiqi Wen, Dingke Xiao, Anqi Guo, Rui You, Chao Liu, Yi |
author_sort | Chen, Ruiqi |
collection | PubMed |
description | BACKGROUND: Although the characteristics of intracranial aneurysms (IAs) in different age groups have been well documented, they remain relatively unclear in elderly patients due to a lack of large sample studies. METHODS: Data from IA patients aged more than 70 years who were treated in our centre from January 2016 to January 2020 were retrospectively collected. RESULTS: A total of 290 elderly patients (75.9% female) with a mean age of 74.0 ± 4.7 years were analysed. Rupture occurred in 60.7% of patients, 38.6% of whom presented with meningeal irritation, and seizures were noted in 2.3%. A total of 48.9% of the patients with ruptured IAs had initial symptoms presenting with slow development, and the mean delay from ictus was prolonged to 264.2 ± 914.0 hours. In addition, 61.9% of the patients with ruptured IAs had lesions with a maximum diameter of less than 5 mm. A total of 30.3% of the patients had multiple aneurysms, 35.5% had aneurysms with irregular shapes and 54.8% had cerebrovascular atherosclerotic stenosis (CAS). Pulmonary infection (n = 138, 47.6%), hydrocephalus (n = 72, 24.8%), and thrombosis (n = 35, 12.1%) were common complications during hospitalization. By the end of the 1-year follow-up, 22.1% of the patients had unfavourable clinical outcomes, and the mortality rate was 23.4%. CONCLUSIONS: Several characteristics regarding IAs in elderly patients were reported, including an obvious female predominance; mild, slow initial symptom development causing prolonged admission delay; a low incidence of meningeal irritation and seizures due to decreased electrophysiological activity of the neurons; increased percentages of CAS, multiple aneurysms, and aneurysms with daughter sacs causing a high risk of rupture even for small lesions; a high risk of complications during hospitalization; and relatively poor clinical outcomes. |
format | Online Article Text |
id | pubmed-9275156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92751562022-07-13 Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study Chen, Ruiqi Wen, Dingke Xiao, Anqi Guo, Rui You, Chao Liu, Yi BMC Neurol Research Article BACKGROUND: Although the characteristics of intracranial aneurysms (IAs) in different age groups have been well documented, they remain relatively unclear in elderly patients due to a lack of large sample studies. METHODS: Data from IA patients aged more than 70 years who were treated in our centre from January 2016 to January 2020 were retrospectively collected. RESULTS: A total of 290 elderly patients (75.9% female) with a mean age of 74.0 ± 4.7 years were analysed. Rupture occurred in 60.7% of patients, 38.6% of whom presented with meningeal irritation, and seizures were noted in 2.3%. A total of 48.9% of the patients with ruptured IAs had initial symptoms presenting with slow development, and the mean delay from ictus was prolonged to 264.2 ± 914.0 hours. In addition, 61.9% of the patients with ruptured IAs had lesions with a maximum diameter of less than 5 mm. A total of 30.3% of the patients had multiple aneurysms, 35.5% had aneurysms with irregular shapes and 54.8% had cerebrovascular atherosclerotic stenosis (CAS). Pulmonary infection (n = 138, 47.6%), hydrocephalus (n = 72, 24.8%), and thrombosis (n = 35, 12.1%) were common complications during hospitalization. By the end of the 1-year follow-up, 22.1% of the patients had unfavourable clinical outcomes, and the mortality rate was 23.4%. CONCLUSIONS: Several characteristics regarding IAs in elderly patients were reported, including an obvious female predominance; mild, slow initial symptom development causing prolonged admission delay; a low incidence of meningeal irritation and seizures due to decreased electrophysiological activity of the neurons; increased percentages of CAS, multiple aneurysms, and aneurysms with daughter sacs causing a high risk of rupture even for small lesions; a high risk of complications during hospitalization; and relatively poor clinical outcomes. BioMed Central 2022-07-11 /pmc/articles/PMC9275156/ /pubmed/35820817 http://dx.doi.org/10.1186/s12883-022-02786-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Chen, Ruiqi Wen, Dingke Xiao, Anqi Guo, Rui You, Chao Liu, Yi Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
title | Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
title_full | Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
title_fullStr | Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
title_full_unstemmed | Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
title_short | Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
title_sort | clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275156/ https://www.ncbi.nlm.nih.gov/pubmed/35820817 http://dx.doi.org/10.1186/s12883-022-02786-z |
work_keys_str_mv | AT chenruiqi clinicalcharacteristicsofintracranialaneurysmsinelderlypatentsover70yearsoldaretrospectiveobservationalstudy AT wendingke clinicalcharacteristicsofintracranialaneurysmsinelderlypatentsover70yearsoldaretrospectiveobservationalstudy AT xiaoanqi clinicalcharacteristicsofintracranialaneurysmsinelderlypatentsover70yearsoldaretrospectiveobservationalstudy AT guorui clinicalcharacteristicsofintracranialaneurysmsinelderlypatentsover70yearsoldaretrospectiveobservationalstudy AT youchao clinicalcharacteristicsofintracranialaneurysmsinelderlypatentsover70yearsoldaretrospectiveobservationalstudy AT liuyi clinicalcharacteristicsofintracranialaneurysmsinelderlypatentsover70yearsoldaretrospectiveobservationalstudy |