α-Gal antigen-deficient rabbits with GGTA1 gene disruption via CRISPR/Cas9

BACKGROUND: Previous studies have identified the carbohydrate epitope Galα1–3Galβ1–4GlcNAc-R (termed the α-galactosyl epitope), known as the α-Gal antigen as the primary xenoantigen recognized by the human immune system. The α-Gal antigen is regulated by galactosyltransferase (GGTA1), and α-Gal anti...

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Detalles Bibliográficos
Autores principales: Wei, Lina, Mu, Yufeng, Deng, Jichao, Wu, Yong, Qiao, Ying, Zhang, Kun, Wang, Xuewen, Huang, Wenpeng, Shao, Anliang, Chen, Liang, Zhang, Yang, Li, Zhanjun, Lai, Liangxue, Qu, Shuxin, Xu, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275273/
https://www.ncbi.nlm.nih.gov/pubmed/35820824
http://dx.doi.org/10.1186/s12863-022-01068-4

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