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Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study
INTRODUCTION: Congenital hypothyroidism is the most preventable and treatable cause of mental retardation in newborns and infants. Screening for congenital hypothyroidism in newborns and infants is not a routine practice in our part of the world. This study aimed to find out the prevalence of congen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Journal of the Nepal Medical Association
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275452/ https://www.ncbi.nlm.nih.gov/pubmed/35690974 http://dx.doi.org/10.31729/jnma.7505 |
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author | Mishra, Bijaya Bhatta, Nisha Keshary Regmi, Mohan Chandra Das, Binod Kumar Lal Khan, Seraj Ahmed Gelal, Basanta Niraula, Apeksha Lamsal, Madhab |
author_facet | Mishra, Bijaya Bhatta, Nisha Keshary Regmi, Mohan Chandra Das, Binod Kumar Lal Khan, Seraj Ahmed Gelal, Basanta Niraula, Apeksha Lamsal, Madhab |
author_sort | Mishra, Bijaya |
collection | PubMed |
description | INTRODUCTION: Congenital hypothyroidism is the most preventable and treatable cause of mental retardation in newborns and infants. Screening for congenital hypothyroidism in newborns and infants is not a routine practice in our part of the world. This study aimed to find out the prevalence of congenital hypothyroidism among infants undergoing thyroid function test in a tertiary care centre. METHODS: A descriptive cross-sectional study was done in the Department of Biochemistry, from laboratory records starting 14(th) April, 2013 to 13(th) April, 2020 after obtaining ethical clearance from the Institutional Review Committee (Reference number: 1502/019). A total of 1243 infants whose thyroid function tests were performed were obtained using convenience sampling. Thyroid-stimulating hormone was categorised per the European Society of Paediatric Endocrinology guidelines. Data were entered and analysed using Microsoft Excel 2011 and the Statistical Package for the Social Sciences version 11.5. Point estimate at a 95% Confidence Interval was calculated along with frequency and percentages for binary data. RESULTS: Among 1243 infants, 56 (4.50%) (3.35-5.65 at 95% Confidence Interval) infants were diagnosed with congenital hypothyroidism. CONCLUSIONS: The prevalence of congenital hypothyroidism was higher than other studies done in similar settings. An unexpected finding of treatment-induced hyperthyroidism was observed, indicating a lack of regular and timely follow-up of infants diagnosed with congenital hypothyroidism. |
format | Online Article Text |
id | pubmed-9275452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Journal of the Nepal Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-92754522023-02-08 Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study Mishra, Bijaya Bhatta, Nisha Keshary Regmi, Mohan Chandra Das, Binod Kumar Lal Khan, Seraj Ahmed Gelal, Basanta Niraula, Apeksha Lamsal, Madhab JNMA J Nepal Med Assoc Original Article INTRODUCTION: Congenital hypothyroidism is the most preventable and treatable cause of mental retardation in newborns and infants. Screening for congenital hypothyroidism in newborns and infants is not a routine practice in our part of the world. This study aimed to find out the prevalence of congenital hypothyroidism among infants undergoing thyroid function test in a tertiary care centre. METHODS: A descriptive cross-sectional study was done in the Department of Biochemistry, from laboratory records starting 14(th) April, 2013 to 13(th) April, 2020 after obtaining ethical clearance from the Institutional Review Committee (Reference number: 1502/019). A total of 1243 infants whose thyroid function tests were performed were obtained using convenience sampling. Thyroid-stimulating hormone was categorised per the European Society of Paediatric Endocrinology guidelines. Data were entered and analysed using Microsoft Excel 2011 and the Statistical Package for the Social Sciences version 11.5. Point estimate at a 95% Confidence Interval was calculated along with frequency and percentages for binary data. RESULTS: Among 1243 infants, 56 (4.50%) (3.35-5.65 at 95% Confidence Interval) infants were diagnosed with congenital hypothyroidism. CONCLUSIONS: The prevalence of congenital hypothyroidism was higher than other studies done in similar settings. An unexpected finding of treatment-induced hyperthyroidism was observed, indicating a lack of regular and timely follow-up of infants diagnosed with congenital hypothyroidism. Journal of the Nepal Medical Association 2022-06 2022-06-30 /pmc/articles/PMC9275452/ /pubmed/35690974 http://dx.doi.org/10.31729/jnma.7505 Text en © The Author(s) 2018. https://creativecommons.org/licenses/by/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mishra, Bijaya Bhatta, Nisha Keshary Regmi, Mohan Chandra Das, Binod Kumar Lal Khan, Seraj Ahmed Gelal, Basanta Niraula, Apeksha Lamsal, Madhab Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study |
title | Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study |
title_full | Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study |
title_fullStr | Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study |
title_full_unstemmed | Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study |
title_short | Congenital Hypothyroidism among Infants Undergoing Thyroid Function Test in a Tertiary Care Centre: A Descriptive Cross-sectional Study |
title_sort | congenital hypothyroidism among infants undergoing thyroid function test in a tertiary care centre: a descriptive cross-sectional study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275452/ https://www.ncbi.nlm.nih.gov/pubmed/35690974 http://dx.doi.org/10.31729/jnma.7505 |
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