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Plant-Derived Human Vaccines: Recent Developments

The idea of producing vaccines in plants originated in the late 1980s. Initially, it was contemplated that this notion could facilitate the concept of edible vaccines, making them more cost effective and easily accessible. Initial studies on edible vaccines focussed on the use of a variety of differ...

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Autores principales: Stander, Jennifer, Mbewana, Sandiswa, Meyers, Ann E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275545/
https://www.ncbi.nlm.nih.gov/pubmed/35821564
http://dx.doi.org/10.1007/s40259-022-00544-8
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author Stander, Jennifer
Mbewana, Sandiswa
Meyers, Ann E.
author_facet Stander, Jennifer
Mbewana, Sandiswa
Meyers, Ann E.
author_sort Stander, Jennifer
collection PubMed
description The idea of producing vaccines in plants originated in the late 1980s. Initially, it was contemplated that this notion could facilitate the concept of edible vaccines, making them more cost effective and easily accessible. Initial studies on edible vaccines focussed on the use of a variety of different transgenic plant host species for the production of vaccine antigens. However, adequate expression levels of antigens, the difficulties predicted with administration of consistent doses, and regulatory rules required for growth of transgenic plants gave way to the development of vaccine candidates that could be purified and administered parenterally. The field has subsequently advanced with improved expression techniques including a shift from using transgenic to transient expression of antigens, refinement of purification protocols, a deeper understanding of the biological processes and a wealth of evidence of immunogenicity and efficacy of plant-produced vaccine candidates, all contributing to the successful practice of what is now known as biopharming or plant molecular farming. The establishment of this technology has resulted in the development of many different types of vaccine candidates including subunit vaccines and various different types of nanoparticle vaccines targeting a wide variety of bacterial and viral diseases. This has brought further acceptance of plants as a suitable platform for vaccine production and in this review, we discuss the most recent advances in the production of vaccines in plants for human use.
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spelling pubmed-92755452022-07-14 Plant-Derived Human Vaccines: Recent Developments Stander, Jennifer Mbewana, Sandiswa Meyers, Ann E. BioDrugs Review Article The idea of producing vaccines in plants originated in the late 1980s. Initially, it was contemplated that this notion could facilitate the concept of edible vaccines, making them more cost effective and easily accessible. Initial studies on edible vaccines focussed on the use of a variety of different transgenic plant host species for the production of vaccine antigens. However, adequate expression levels of antigens, the difficulties predicted with administration of consistent doses, and regulatory rules required for growth of transgenic plants gave way to the development of vaccine candidates that could be purified and administered parenterally. The field has subsequently advanced with improved expression techniques including a shift from using transgenic to transient expression of antigens, refinement of purification protocols, a deeper understanding of the biological processes and a wealth of evidence of immunogenicity and efficacy of plant-produced vaccine candidates, all contributing to the successful practice of what is now known as biopharming or plant molecular farming. The establishment of this technology has resulted in the development of many different types of vaccine candidates including subunit vaccines and various different types of nanoparticle vaccines targeting a wide variety of bacterial and viral diseases. This has brought further acceptance of plants as a suitable platform for vaccine production and in this review, we discuss the most recent advances in the production of vaccines in plants for human use. Springer International Publishing 2022-07-12 2022 /pmc/articles/PMC9275545/ /pubmed/35821564 http://dx.doi.org/10.1007/s40259-022-00544-8 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Stander, Jennifer
Mbewana, Sandiswa
Meyers, Ann E.
Plant-Derived Human Vaccines: Recent Developments
title Plant-Derived Human Vaccines: Recent Developments
title_full Plant-Derived Human Vaccines: Recent Developments
title_fullStr Plant-Derived Human Vaccines: Recent Developments
title_full_unstemmed Plant-Derived Human Vaccines: Recent Developments
title_short Plant-Derived Human Vaccines: Recent Developments
title_sort plant-derived human vaccines: recent developments
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275545/
https://www.ncbi.nlm.nih.gov/pubmed/35821564
http://dx.doi.org/10.1007/s40259-022-00544-8
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