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Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition

Cyp2a12(-/-)Cyp2c70(-/-) double knockout (DKO) mice have a human-like hydrophobic bile acid (BA) composition and show reduced fertility and liver injury. Ursodeoxycholic acid (UDCA) is a hydrophilic and cytoprotective BA used to treat various liver injuries in humans. This study investigated the eff...

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Detalles Bibliográficos
Autores principales:	Ueda, Hajime, Honda, Akira, Miyazaki, Teruo, Morishita, Yukio, Hirayama, Takeshi, Iwamoto, Junichi, Nakamoto, Nobuhiro, Ikegami, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275687/ https://www.ncbi.nlm.nih.gov/pubmed/35819971 http://dx.doi.org/10.1371/journal.pone.0271308

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