Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis

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While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203–205 in the SARS-CoV-2 nucleocapsid protein. Recreating a mutation found in the alpha and...

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Detalles Bibliográficos
Autores principales: Johnson, Bryan A., Zhou, Yiyang, Lokugamage, Kumari G., Vu, Michelle N., Bopp, Nathen, Crocquet-Valdes, Patricia A., Kalveram, Birte, Schindewolf, Craig, Liu, Yang, Scharton, Dionna, Plante, Jessica A., Xie, Xuping, Aguilar, Patricia, Weaver, Scott C., Shi, Pei-Yong, Walker, David H., Routh, Andrew L., Plante, Kenneth S., Menachery, Vineet D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275689/
https://www.ncbi.nlm.nih.gov/pubmed/35728038
http://dx.doi.org/10.1371/journal.ppat.1010627
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