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A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection

The HIV/SIV envelope glycoprotein (Env) cytoplasmic domain contains a highly conserved Tyr-based trafficking signal that mediates both clathrin-dependent endocytosis and polarized sorting. Despite extensive analysis, the role of these functions in viral infection and pathogenesis is unclear. An SIV...

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Detalles Bibliográficos
Autores principales:	Lawrence, Scott P., Elser, Samra E., Torben, Workineh, Blair, Robert V., Pahar, Bapi, Aye, Pyone P., Schiro, Faith, Szeltner, Dawn, Doyle-Meyers, Lara A., Haggarty, Beth S., Jordan, Andrea P. O., Romano, Josephine, Leslie, George J., Alvarez, Xavier, O’Connor, David H., Wiseman, Roger W., Fennessey, Christine M., Li, Yuan, Piatak, Michael, Lifson, Jeffrey D., LaBranche, Celia C., Lackner, Andrew A., Keele, Brandon F., Maness, Nicholas J., Marsh, Mark, Hoxie, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275724/ https://www.ncbi.nlm.nih.gov/pubmed/35714165 http://dx.doi.org/10.1371/journal.ppat.1010507

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