Convallatoxin suppresses osteosarcoma cell proliferation, migration, invasion, and enhances osteogenic differentiation by downregulating parathyroid hormone receptor 1 (PTHR1) expression and inactivating Wnt/β-catenin pathway

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Convallatoxin, a natural cardiac glycoside, exhibits potent anti-tumor activities. Literature has confirmed that PTHR1 is highly expressed in OS tissues and cells and downregulation of PTHR1 could decrease...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Geng, Ze, Ding, Xiangyong, Lou, Yan, Zhang, Xingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275893/
https://www.ncbi.nlm.nih.gov/pubmed/35635031
http://dx.doi.org/10.1080/21655979.2022.2080363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275893/
https://www.ncbi.nlm.nih.gov/pubmed/35635031
http://dx.doi.org/10.1080/21655979.2022.2080363

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