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Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors

Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a type of RNA molecule that includes mRNA of coding-protein, pseudogenes, long non-codi...

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Autores principales: Mao, Mingwen, Zhang, Jingyu, Xiang, Yizhen, Gong, Mengdan, Deng, Yongqin, Ye, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275901/
https://www.ncbi.nlm.nih.gov/pubmed/35577352
http://dx.doi.org/10.1080/21655979.2022.2073130
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author Mao, Mingwen
Zhang, Jingyu
Xiang, Yizhen
Gong, Mengdan
Deng, Yongqin
Ye, Dong
author_facet Mao, Mingwen
Zhang, Jingyu
Xiang, Yizhen
Gong, Mengdan
Deng, Yongqin
Ye, Dong
author_sort Mao, Mingwen
collection PubMed
description Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a type of RNA molecule that includes mRNA of coding-protein, pseudogenes, long non-coding RNA (lncRNA), and circular RNA (circRNA) etc. It is created through a competitive combination of common small RNA (miRNA) and has an inhibitory effect on mRNA translation. ceRNA regulate the post transcriptional expression of genes by competitively binding to common microRNAs (miRNAs).Studies have shown that cernas are involved in tumor cell proliferation, invasion and migration, drug resistance, angiogenesis, as well as tumor immunity, and so on, affecting the progression of tumor development. This article reviews the reported roles of exosomal ceRNA in the diagnosis and treatment of malignant tumors and the mechanisms underlying these.
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spelling pubmed-92759012022-07-13 Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors Mao, Mingwen Zhang, Jingyu Xiang, Yizhen Gong, Mengdan Deng, Yongqin Ye, Dong Bioengineered Review Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a type of RNA molecule that includes mRNA of coding-protein, pseudogenes, long non-coding RNA (lncRNA), and circular RNA (circRNA) etc. It is created through a competitive combination of common small RNA (miRNA) and has an inhibitory effect on mRNA translation. ceRNA regulate the post transcriptional expression of genes by competitively binding to common microRNAs (miRNAs).Studies have shown that cernas are involved in tumor cell proliferation, invasion and migration, drug resistance, angiogenesis, as well as tumor immunity, and so on, affecting the progression of tumor development. This article reviews the reported roles of exosomal ceRNA in the diagnosis and treatment of malignant tumors and the mechanisms underlying these. Taylor & Francis 2022-05-16 /pmc/articles/PMC9275901/ /pubmed/35577352 http://dx.doi.org/10.1080/21655979.2022.2073130 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mao, Mingwen
Zhang, Jingyu
Xiang, Yizhen
Gong, Mengdan
Deng, Yongqin
Ye, Dong
Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
title Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
title_full Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
title_fullStr Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
title_full_unstemmed Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
title_short Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
title_sort role of exosomal competitive endogenous rna (cerna) in diagnosis and treatment of malignant tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275901/
https://www.ncbi.nlm.nih.gov/pubmed/35577352
http://dx.doi.org/10.1080/21655979.2022.2073130
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