Cargando…

Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation

In this study, we employed multiple laboratory techniques to acknowledge the biological activities and processes of Per2 and Id3 in glioma. We analyzed TCGA and CGGA databases for seeking association among Per2, Id3, and clinical features in glioma. Immunohistochemistry and Western blot were used to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yifan, Hu, Xvlei, Li, Hailiang, Yao, Jian, Yang, Ping, Lan, Yuanxiang, Xia, Hechun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275974/ https://www.ncbi.nlm.nih.gov/pubmed/35599595 http://dx.doi.org/10.1080/21655979.2022.2074107

Ejemplares similares

Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
por: Zhanfeng, Niu, et al.
Publicado: (2015)

Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and neuronal damage following spinal cord injury
por: Hu, Xvlei, et al.
Publicado: (2022)

PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/β-catenin signaling pathway
por: Ma, Dede, et al.
Publicado: (2020)

Integrated transcriptomic and metabolomic profiling reveals dysregulation of purine metabolism during the acute phase of spinal cord injury in rats
por: Zeng, Zhong, et al.
Publicado: (2022)

Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation
por: Eritja, Núria, et al.
Publicado: (2021)

Per2 attenuates LPS-induced chondrocyte injury through the PTEN/PI3K/Akt signalling pathway
por: Zhao, Yu, et al.
Publicado: (2020)

Hippocampal Mitochondrial Abnormalities Induced the Dendritic Complexity Reduction and Cognitive Decline in a Rat Model of Spinal Cord Injury
por: Hu, Xvlei, et al.
Publicado: (2022)

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma
por: Sato, Aya, et al.
Publicado: (2017)

Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2
por: Aviram, Rona, et al.
Publicado: (2021)

Retraction: Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
Publicado: (2020)

Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway
por: Zhanfeng, Niu, et al.
Publicado: (2016)

ATF3 suppresses ESCC via downregulation of ID1
por: Li, Jian, et al.
Publicado: (2016)

Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients
por: Faltraco, Frank, et al.
Publicado: (2021)

Circadian behavior of mice deficient in PER1/PML or PER2/PML
por: Miki, Takao, et al.
Publicado: (2013)

Per1/Per2–Igf2 axis–mediated circadian regulation of myogenic differentiation
por: Katoku-Kikyo, Nobuko, et al.
Publicado: (2021)

Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma
por: Niu, Hai-Tao, et al.
Publicado: (2021)

Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas
por: Erira, Alveiro, et al.
Publicado: (2021)

PER2 integrates circadian disruption and pituitary tumorigenesis
por: Guo, Lianxia, et al.
Publicado: (2023)

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
por: Hayasaka, Naoto, et al.
Publicado: (2017)

MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway
por: Luo, Mao, et al.
Publicado: (2017)

Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice
por: Ralph, Martin R., et al.
Publicado: (2021)

Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4
por: Casali, Paolo, et al.
Publicado: (2021)

The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice
por: Pereira, D. S., et al.
Publicado: (2014)

Circadian Gene PER2 Silencing Downregulates PPARG and SREBF1 and Suppresses Lipid Synthesis in Bovine Mammary Epithelial Cells
por: Jing, Yujia, et al.
Publicado: (2021)

A Role for Id2 in Regulating Photic Entrainment of the Mammalian Circadian System
por: Duffield, Giles E., et al.
Publicado: (2009)

Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma [Retraction]
Publicado: (2021)

Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2
por: Kim, Mikyung, et al.
Publicado: (2018)

Correction: Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
por: Hayasaka, Naoto, et al.
Publicado: (2021)

Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity
por: Lindberg, Karolina, et al.
Publicado: (2011)

Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch
por: Masuda, Shusaku, et al.
Publicado: (2020)

SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway
por: Liu, Chuanjin, et al.
Publicado: (2017)

ID2 Inhibits Bladder Cancer Progression and Metastasis via PI3K/AKT Signaling Pathway
por: Mao, Weipu, et al.
Publicado: (2021)

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures
por: Parsons, Michael J, et al.
Publicado: (2014)

Identification of the proliferative effect of Smad2 and 3 in the TGF β2/Smad signaling pathway using RNA interference in a glioma cell line
por: DONG, CHENGYUAN, et al.
Publicado: (2015)

Circadian rhythms in Per1, PER2 and Ca(2+) of a solitary SCN neuron cultured on a microisland
por: Hirata, Yoshihiro, et al.
Publicado: (2019)

Downregulation of Id1 by small interfering RNA in gastric cancer inhibits cell growth via the Akt pathway
por: YANG, GUANG, et al.
Publicado: (2012)

GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling
por: Wu, Ze, et al.
Publicado: (2023)

The Circadian Gene Per1 Plays an Important Role in Radiation-Induced Apoptosis and DNA Damage in Glioma
por: Zhu, Ling, et al.
Publicado: (2019)

Circadian Clock Gene Per2 Is Not Necessary for the Photoperiodic Response in Mice
por: Ikegami, Keisuke, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_n9n4seiercvou86llje1d69h8d