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CRISPR/Cas9 (D10A) nickase-mediated Hb CS gene editing and genetically modified fibroblast identification

This study investigated whether CRISPR/Cas9 (D10A) nickase-mediated gene editing can correct the aberrant Hb Constant Spring mutation (Hb CS or HBA2: c.427 T > C) in fibroblasts. Vectors for repairing the α-globin-encoding gene, HBA2:c.427 T > C mutation, includingthe CRISPR/Cas9(D10A)-sg plas...

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Detalles Bibliográficos
Autores principales:	Wu, Wei-Hao, Ma, Xiao-Mei, Huang, Jian-Qing, Lai, Qin, Jiang, Fu-Neng, Zou, Cui-Yun, Chen, Long-Tian, Yu, Lian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276056/ https://www.ncbi.nlm.nih.gov/pubmed/36700476 http://dx.doi.org/10.1080/21655979.2022.2069940

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