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Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China

BACKGROUND: Family clustering of esophageal cancer (EC) has been found in high-risk areas of China. However, the relationships between cancer family history and esophageal cancer and precancerous lesions (ECPL) have not been comprehensively reported in recent years. This study aimed to provide evide...

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Autores principales: Zhou, Jiachen, Sun, Kexin, Wang, Shaoming, Chen, Ru, Li, Minjuan, Gu, Jianhua, Fan, Zhiyuan, Zhuang, Guihua, Wei, Wenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276202/
https://www.ncbi.nlm.nih.gov/pubmed/35026773
http://dx.doi.org/10.1097/CM9.0000000000001939
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author Zhou, Jiachen
Sun, Kexin
Wang, Shaoming
Chen, Ru
Li, Minjuan
Gu, Jianhua
Fan, Zhiyuan
Zhuang, Guihua
Wei, Wenqiang
author_facet Zhou, Jiachen
Sun, Kexin
Wang, Shaoming
Chen, Ru
Li, Minjuan
Gu, Jianhua
Fan, Zhiyuan
Zhuang, Guihua
Wei, Wenqiang
author_sort Zhou, Jiachen
collection PubMed
description BACKGROUND: Family clustering of esophageal cancer (EC) has been found in high-risk areas of China. However, the relationships between cancer family history and esophageal cancer and precancerous lesions (ECPL) have not been comprehensively reported in recent years. This study aimed to provide evidence for identification of high-risk populations. METHODS: This study was conducted in five high-risk areas in China from 2017 to 2019, based on the National Cohort of Esophageal Cancer. The permanent residents aged 40 to 69 years were examined by endoscopy, and pathological examination was performed for suspicious lesions. Information on demographic characteristics, environmental factors, and cancer family history was collected. Unconditional logistic regression was applied to evaluate odds ratios between family history related factors and ECPL. RESULTS: Among 33,008 participants, 6143 (18.61%) reported positive family history of EC. The proportion of positive family history varied significantly among high-risk areas. After adjusting for risk factors, participants with a family history of positive cancer, gastric and esophageal cancer or EC had 1.49-fold (95% confidence interval [CI]: 1.36–1.62), 1.52-fold (95% CI: 1.38–1.67), or 1.66-fold (95% CI: 1.50–1.84) higher risks of ECPL, respectively. Participants with single or multiple first-degree relatives (FDR) of positive EC history had 1.65-fold (95% CI: 1.47–1.84) or 1.93-fold (95% CI: 1.46–2.54) higher risks of ECPL. Participants with FDRs who developed EC before 35, 45, and 50 years of age had 4.05-fold (95% CI: 1.30–12.65), 2.11-fold (95% CI: 1.37–3.25), and 1.91-fold (95% CI: 1.44–2.54) higher risks of ECPL, respectively. CONCLUSIONS: Participants with positive family history of EC had significantly higher risk of ECPL. This risk increased with the number of EC positive FDRs and EC family history of early onset. Distinctive genetic risk factors of the population in high-risk areas of China require further investigation. TRIAL REGISTRATION: ChiCTR-EOC-17010553.
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spelling pubmed-92762022022-07-13 Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China Zhou, Jiachen Sun, Kexin Wang, Shaoming Chen, Ru Li, Minjuan Gu, Jianhua Fan, Zhiyuan Zhuang, Guihua Wei, Wenqiang Chin Med J (Engl) Original Articles BACKGROUND: Family clustering of esophageal cancer (EC) has been found in high-risk areas of China. However, the relationships between cancer family history and esophageal cancer and precancerous lesions (ECPL) have not been comprehensively reported in recent years. This study aimed to provide evidence for identification of high-risk populations. METHODS: This study was conducted in five high-risk areas in China from 2017 to 2019, based on the National Cohort of Esophageal Cancer. The permanent residents aged 40 to 69 years were examined by endoscopy, and pathological examination was performed for suspicious lesions. Information on demographic characteristics, environmental factors, and cancer family history was collected. Unconditional logistic regression was applied to evaluate odds ratios between family history related factors and ECPL. RESULTS: Among 33,008 participants, 6143 (18.61%) reported positive family history of EC. The proportion of positive family history varied significantly among high-risk areas. After adjusting for risk factors, participants with a family history of positive cancer, gastric and esophageal cancer or EC had 1.49-fold (95% confidence interval [CI]: 1.36–1.62), 1.52-fold (95% CI: 1.38–1.67), or 1.66-fold (95% CI: 1.50–1.84) higher risks of ECPL, respectively. Participants with single or multiple first-degree relatives (FDR) of positive EC history had 1.65-fold (95% CI: 1.47–1.84) or 1.93-fold (95% CI: 1.46–2.54) higher risks of ECPL. Participants with FDRs who developed EC before 35, 45, and 50 years of age had 4.05-fold (95% CI: 1.30–12.65), 2.11-fold (95% CI: 1.37–3.25), and 1.91-fold (95% CI: 1.44–2.54) higher risks of ECPL, respectively. CONCLUSIONS: Participants with positive family history of EC had significantly higher risk of ECPL. This risk increased with the number of EC positive FDRs and EC family history of early onset. Distinctive genetic risk factors of the population in high-risk areas of China require further investigation. TRIAL REGISTRATION: ChiCTR-EOC-17010553. Lippincott Williams & Wilkins 2022-04-05 2022-01-13 /pmc/articles/PMC9276202/ /pubmed/35026773 http://dx.doi.org/10.1097/CM9.0000000000001939 Text en Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Articles
Zhou, Jiachen
Sun, Kexin
Wang, Shaoming
Chen, Ru
Li, Minjuan
Gu, Jianhua
Fan, Zhiyuan
Zhuang, Guihua
Wei, Wenqiang
Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China
title Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China
title_full Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China
title_fullStr Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China
title_full_unstemmed Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China
title_short Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China
title_sort associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of china
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276202/
https://www.ncbi.nlm.nih.gov/pubmed/35026773
http://dx.doi.org/10.1097/CM9.0000000000001939
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