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Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients

OBJECTIVE: To explore the effects of high-flux hemodialysis combined with L-carnitine on microinflammation and arteriovenous fistulas in maintenance hemodialysis patients. METHODS: A total of 65 patients admitted to our hospital from May 2017 to May 2019 were selected and divided into a control grou...

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Autor principal: Zhou, Yunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276479/
https://www.ncbi.nlm.nih.gov/pubmed/35836826
http://dx.doi.org/10.1155/2022/6964127
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author Zhou, Yunhong
author_facet Zhou, Yunhong
author_sort Zhou, Yunhong
collection PubMed
description OBJECTIVE: To explore the effects of high-flux hemodialysis combined with L-carnitine on microinflammation and arteriovenous fistulas in maintenance hemodialysis patients. METHODS: A total of 65 patients admitted to our hospital from May 2017 to May 2019 were selected and divided into a control group of 30 cases and an experimental group of 35 cases according to the selected treatment plan. Combined with L-carnitine, the cardiac function of the two groups of patients before and after the treatment was evaluated, the microinflammatory indexes of the two groups were compared, and the clinical efficacy of the combined treatment on MHD patients was analyzed. RESULTS: The two groups were not significantly different in general information such as age, gender, course of disease, and past medical history (P > 0.05). The experimental group generated a notably higher total effective rate of treatment in relation to the control group (P < 0.05). After treatment, lower heart function levels of LVST and LEVDD were observed in the experimental group as compared to the control group, but LVEF was higher than that in the control group (P < 0.05). The GQOLI-74 score of the experimental group was better than that of the control group (P < 0.05). The incidence of venous fistula complications in the experimental group was significantly lower than that in the control group (P < 0.05). The microinflammatory index hs-CRP in the experimental group was lower (P < 0.05) and the microinflammatory index TNF-α was significantly lower (P < 0.05). The HAD score after treatment of the experimental group was better than that of the control group (P < 0.05). CONCLUSION: High-flux hemodialysis combined with L-carnitine therapy has achieved satisfactory results in patients with MHD in terms of alleviating the level of inflammatory factors, improving heart function, enhancing patients' living standards, reducing complications of intravenous fistula, and boosting the prognosis. It is worthy of promotion.
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spelling pubmed-92764792022-07-13 Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients Zhou, Yunhong Evid Based Complement Alternat Med Research Article OBJECTIVE: To explore the effects of high-flux hemodialysis combined with L-carnitine on microinflammation and arteriovenous fistulas in maintenance hemodialysis patients. METHODS: A total of 65 patients admitted to our hospital from May 2017 to May 2019 were selected and divided into a control group of 30 cases and an experimental group of 35 cases according to the selected treatment plan. Combined with L-carnitine, the cardiac function of the two groups of patients before and after the treatment was evaluated, the microinflammatory indexes of the two groups were compared, and the clinical efficacy of the combined treatment on MHD patients was analyzed. RESULTS: The two groups were not significantly different in general information such as age, gender, course of disease, and past medical history (P > 0.05). The experimental group generated a notably higher total effective rate of treatment in relation to the control group (P < 0.05). After treatment, lower heart function levels of LVST and LEVDD were observed in the experimental group as compared to the control group, but LVEF was higher than that in the control group (P < 0.05). The GQOLI-74 score of the experimental group was better than that of the control group (P < 0.05). The incidence of venous fistula complications in the experimental group was significantly lower than that in the control group (P < 0.05). The microinflammatory index hs-CRP in the experimental group was lower (P < 0.05) and the microinflammatory index TNF-α was significantly lower (P < 0.05). The HAD score after treatment of the experimental group was better than that of the control group (P < 0.05). CONCLUSION: High-flux hemodialysis combined with L-carnitine therapy has achieved satisfactory results in patients with MHD in terms of alleviating the level of inflammatory factors, improving heart function, enhancing patients' living standards, reducing complications of intravenous fistula, and boosting the prognosis. It is worthy of promotion. Hindawi 2022-07-05 /pmc/articles/PMC9276479/ /pubmed/35836826 http://dx.doi.org/10.1155/2022/6964127 Text en Copyright © 2022 Yunhong Zhou. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Yunhong
Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients
title Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients
title_full Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients
title_fullStr Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients
title_full_unstemmed Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients
title_short Effects of High Flux Hemodialysis Combined with L-Carnitine on Microinflammation and Arteriovenous Fistula in Maintenance Hemodialysis Patients
title_sort effects of high flux hemodialysis combined with l-carnitine on microinflammation and arteriovenous fistula in maintenance hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276479/
https://www.ncbi.nlm.nih.gov/pubmed/35836826
http://dx.doi.org/10.1155/2022/6964127
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