Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome

Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations in cancer or to germline mutations that are transmitted to the next generation. It is not known whether any mechanism exists in the germ line to control...

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Detalles Bibliográficos
Autores principales: Meng, Yingying, Wang, Guliang, He, Hongjuan, Lau, Kin H., Hurt, Allison, Bixler, Brianna J., Parham, Andrea, Jin, Seung-Gi, Xu, Xingzhi, Vasquez, Karen M., Pfeifer, Gerd P., Szabó, Piroska E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276527/
https://www.ncbi.nlm.nih.gov/pubmed/35787683
http://dx.doi.org/10.1038/s41556-022-00941-9

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