Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling

Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address the hypothesis that inappropriate pro-inflammatory mechanisms contribute to the pathogenesis of refractory epilepsy (non-responsiveness to antiepileptic drugs) in human patients. We used single-cell cellular...

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Detalles Bibliográficos
Autores principales: Kumar, Pavanish, Lim, Amanda, Hazirah, Sharifah Nur, Chua, Camillus Jian Hui, Ngoh, Adeline, Poh, Su Li, Yeo, Tong Hong, Lim, Jocelyn, Ling, Simon, Sutamam, Nursyuhadah Binte, Petretto, Enrico, Low, David Chyi Yeu, Zeng, Li, Tan, Eng-King, Arkachaisri, Thaschawee, Yeo, Joo Guan, Ginhoux, Florent, Chan, Derrick, Albani, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276529/
https://www.ncbi.nlm.nih.gov/pubmed/35739273
http://dx.doi.org/10.1038/s41593-022-01095-5

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