Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. Whether HSC dormancy exists...

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Detalles Bibliográficos
Autores principales: Zhang, Yu Wei, Mess, Julian, Aizarani, Nadim, Mishra, Pankaj, Johnson, Carys, Romero-Mulero, Mari Carmen, Rettkowski, Jasmin, Schönberger, Katharina, Obier, Nadine, Jäcklein, Karin, Woessner, Nadine M., Lalioti, Maria-Eleni, Velasco-Hernandez, Talia, Sikora, Katarzyna, Wäsch, Ralph, Lehnertz, Bernhard, Sauvageau, Guy, Manke, Thomas, Menendez, Pablo, Walter, Sebastian Gottfried, Minguet, Susana, Laurenti, Elisa, Günther, Stefan, Grün, Dominic, Cabezas-Wallscheid, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276531/
https://www.ncbi.nlm.nih.gov/pubmed/35725769
http://dx.doi.org/10.1038/s41556-022-00931-x

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