Cargando…

Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic

OBJECTIVES: Here, we retrospectively described the diagnosis and treatment of 32 cases diagnosed with Chlamydia psittaci pneumonia during the COVID-19 pandemic. METHODS: Clinical information was collected from all the patients. Reverse transcription–PCR and ELISAs were conducted for the detection of...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Qiaoqiao, Li, Yuecui, Pan, Hongyi, Hui, Tianchen, Yu, Zhaonan, Wu, Haiyan, Zhang, Dehe, Zheng, Wei, Wang, Shouhao, Zhou, Zhewen, Xu, Chengan, Wu, Wenhao, Tong, Yongxi, Wang, Haoyi, Pan, Hongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276535/
https://www.ncbi.nlm.nih.gov/pubmed/35842216
http://dx.doi.org/10.1016/j.ijid.2022.07.027
_version_ 1784745751885119488
author Yin, Qiaoqiao
Li, Yuecui
Pan, Hongyi
Hui, Tianchen
Yu, Zhaonan
Wu, Haiyan
Zhang, Dehe
Zheng, Wei
Wang, Shouhao
Zhou, Zhewen
Xu, Chengan
Wu, Wenhao
Tong, Yongxi
Wang, Haoyi
Pan, Hongying
author_facet Yin, Qiaoqiao
Li, Yuecui
Pan, Hongyi
Hui, Tianchen
Yu, Zhaonan
Wu, Haiyan
Zhang, Dehe
Zheng, Wei
Wang, Shouhao
Zhou, Zhewen
Xu, Chengan
Wu, Wenhao
Tong, Yongxi
Wang, Haoyi
Pan, Hongying
author_sort Yin, Qiaoqiao
collection PubMed
description OBJECTIVES: Here, we retrospectively described the diagnosis and treatment of 32 cases diagnosed with Chlamydia psittaci pneumonia during the COVID-19 pandemic. METHODS: Clinical information was collected from all the patients. Reverse transcription–PCR and ELISAs were conducted for the detection of COVID-19 using nasal swabs and bronchoalveolar lavage fluid (BALF) samples. Metagenomic next-generation sequencing (mNGS) was performed for the identification of causative pathogens using BALF, peripheral blood and sputum samples. End-point PCR was performed to confirm the mNGS results. RESULTS: All 32 patients showed atypical pneumonia and had infection-like symptoms that were similar to COVID-19. Results of reverse transcription–PCR and ELISAs ruled out COVID-19 infection. mNGS identified C. psittaci as the suspected pathogen in these patients within 48 hours, which was validated by PCR, except for three blood samples. The sequence reads that covered fragments of C. psittaci genome were detected more often in BALF than in sputum or blood samples. All patients received doxycycline-based treatment regimens and showed favorable outcomes. CONCLUSION: This retrospective study, with the highest number of C. psittaci pneumonia enrolled cases in China so far, suggests that human psittacosis may be underdiagnosed and misdiagnosed clinically, especially in the midst of the COVID-19 pandemic.
format Online
Article
Text
id pubmed-9276535
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
record_format MEDLINE/PubMed
spelling pubmed-92765352022-07-14 Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic Yin, Qiaoqiao Li, Yuecui Pan, Hongyi Hui, Tianchen Yu, Zhaonan Wu, Haiyan Zhang, Dehe Zheng, Wei Wang, Shouhao Zhou, Zhewen Xu, Chengan Wu, Wenhao Tong, Yongxi Wang, Haoyi Pan, Hongying Int J Infect Dis Article OBJECTIVES: Here, we retrospectively described the diagnosis and treatment of 32 cases diagnosed with Chlamydia psittaci pneumonia during the COVID-19 pandemic. METHODS: Clinical information was collected from all the patients. Reverse transcription–PCR and ELISAs were conducted for the detection of COVID-19 using nasal swabs and bronchoalveolar lavage fluid (BALF) samples. Metagenomic next-generation sequencing (mNGS) was performed for the identification of causative pathogens using BALF, peripheral blood and sputum samples. End-point PCR was performed to confirm the mNGS results. RESULTS: All 32 patients showed atypical pneumonia and had infection-like symptoms that were similar to COVID-19. Results of reverse transcription–PCR and ELISAs ruled out COVID-19 infection. mNGS identified C. psittaci as the suspected pathogen in these patients within 48 hours, which was validated by PCR, except for three blood samples. The sequence reads that covered fragments of C. psittaci genome were detected more often in BALF than in sputum or blood samples. All patients received doxycycline-based treatment regimens and showed favorable outcomes. CONCLUSION: This retrospective study, with the highest number of C. psittaci pneumonia enrolled cases in China so far, suggests that human psittacosis may be underdiagnosed and misdiagnosed clinically, especially in the midst of the COVID-19 pandemic. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-09 2022-07-13 /pmc/articles/PMC9276535/ /pubmed/35842216 http://dx.doi.org/10.1016/j.ijid.2022.07.027 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yin, Qiaoqiao
Li, Yuecui
Pan, Hongyi
Hui, Tianchen
Yu, Zhaonan
Wu, Haiyan
Zhang, Dehe
Zheng, Wei
Wang, Shouhao
Zhou, Zhewen
Xu, Chengan
Wu, Wenhao
Tong, Yongxi
Wang, Haoyi
Pan, Hongying
Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic
title Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic
title_full Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic
title_fullStr Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic
title_full_unstemmed Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic
title_short Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic
title_sort atypical pneumonia caused by chlamydia psittaci during the covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276535/
https://www.ncbi.nlm.nih.gov/pubmed/35842216
http://dx.doi.org/10.1016/j.ijid.2022.07.027
work_keys_str_mv AT yinqiaoqiao atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT liyuecui atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT panhongyi atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT huitianchen atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT yuzhaonan atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT wuhaiyan atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT zhangdehe atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT zhengwei atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT wangshouhao atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT zhouzhewen atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT xuchengan atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT wuwenhao atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT tongyongxi atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT wanghaoyi atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic
AT panhongying atypicalpneumoniacausedbychlamydiapsittaciduringthecovid19pandemic