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COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections
Opportunistic infections, including fungal infections, are dreaded complications of liver transplantation, particularly early after transplant. We describe the case of a patient that presented 6 years after liver transplant with a Lichtheimia corymbifera-infected leg ulcer, following previous COVID-...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Masson SAS.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276538/ https://www.ncbi.nlm.nih.gov/pubmed/38013988 http://dx.doi.org/10.1016/j.liver.2022.100113 |
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author | Pagano, Giulia García, Adriana Cancino-Abarca, Sergio Hernández-Évole, Helena Olivas, Ignasi Marco, Francesc Casaudoumecq, Alfredo Bodro, Marta Crespo, Gonzalo |
author_facet | Pagano, Giulia García, Adriana Cancino-Abarca, Sergio Hernández-Évole, Helena Olivas, Ignasi Marco, Francesc Casaudoumecq, Alfredo Bodro, Marta Crespo, Gonzalo |
author_sort | Pagano, Giulia |
collection | PubMed |
description | Opportunistic infections, including fungal infections, are dreaded complications of liver transplantation, particularly early after transplant. We describe the case of a patient that presented 6 years after liver transplant with a Lichtheimia corymbifera-infected leg ulcer, following previous COVID-19 infection and moderate rejection requiring steroid pulses. The patient required long-term antifungal therapy, repeated surgical debridement and eventually wound coverage with meshed split-thickness skin graft. Our case illustrates the challenges in the treatment of cutaneous mucormycosis and highlights the difficulties in achieving an accurate balance between the risk of opportunistic infections and rejection in this population. |
format | Online Article Text |
id | pubmed-9276538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). Published by Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92765382022-07-14 COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections Pagano, Giulia García, Adriana Cancino-Abarca, Sergio Hernández-Évole, Helena Olivas, Ignasi Marco, Francesc Casaudoumecq, Alfredo Bodro, Marta Crespo, Gonzalo Journal of Liver Transplantation Case Report Opportunistic infections, including fungal infections, are dreaded complications of liver transplantation, particularly early after transplant. We describe the case of a patient that presented 6 years after liver transplant with a Lichtheimia corymbifera-infected leg ulcer, following previous COVID-19 infection and moderate rejection requiring steroid pulses. The patient required long-term antifungal therapy, repeated surgical debridement and eventually wound coverage with meshed split-thickness skin graft. Our case illustrates the challenges in the treatment of cutaneous mucormycosis and highlights the difficulties in achieving an accurate balance between the risk of opportunistic infections and rejection in this population. The Author(s). Published by Elsevier Masson SAS. 2022 2022-07-13 /pmc/articles/PMC9276538/ /pubmed/38013988 http://dx.doi.org/10.1016/j.liver.2022.100113 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Case Report Pagano, Giulia García, Adriana Cancino-Abarca, Sergio Hernández-Évole, Helena Olivas, Ignasi Marco, Francesc Casaudoumecq, Alfredo Bodro, Marta Crespo, Gonzalo COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
title | COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
title_full | COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
title_fullStr | COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
title_full_unstemmed | COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
title_short | COVID-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
title_sort | covid-19, rejection, and cutaneous mucormycosis in a long-term liver transplant recipient – the vicious cycle of immunosuppression and opportunistic infections |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276538/ https://www.ncbi.nlm.nih.gov/pubmed/38013988 http://dx.doi.org/10.1016/j.liver.2022.100113 |
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