SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency

Beyond well-assessed risk factors, cardiovascular events could be also associated with the presence of epigenetic and genetic alterations, such as the methylenetetrahydrofolate-reductase (MTHFR) C677T polymorphism. This gene variant is related to increased circulating levels of homocysteine (Hcy) an...

Descripción completa

Detalles Bibliográficos
Autores principales: Carrizzo, Albino, Iside, Concetta, Nebbioso, Angela, Carafa, Vincenzo, Damato, Antonio, Sciarretta, Sebastiano, Frati, Giacomo, Di Nonno, Flavio, Valenti, Valentina, Ciccarelli, Michele, Venturini, Eleonora, Scioli, Mariarosaria, Di Pietro, Paola, Bucci, Tommaso, Giudice, Valentina, Storto, Marianna, Serio, Bianca, Puca, Annibale Alessandro, Giugliano, Giuseppe, Trimarco, Valentina, Izzo, Raffaele, Trimarco, Bruno, Selleri, Carmine, Altucci, Lucia, Vecchione, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276577/
https://www.ncbi.nlm.nih.gov/pubmed/35821533
http://dx.doi.org/10.1007/s00018-022-04429-5

Ejemplares similares

Ejemplares similares