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Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci

Polyamines are small cationic molecules that have been linked to various cellular processes including replication, translation, stress response and recently, capsule regulation in Streptococcus pneumoniae (Spn, pneumococcus). Pneumococcal-associated diseases such as pneumonia, meningitis, and sepsis...

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Detalles Bibliográficos
Autores principales:	Ayoola, Moses B., Shack, Leslie A., Lee, Jung Hwa, Lim, Juhyeon, Eoh, Hyungjin, Swiatlo, Edwin, Phanstiel, Otto, Nanduri, Bindu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276676/ https://www.ncbi.nlm.nih.gov/pubmed/35821246 http://dx.doi.org/10.1038/s41598-022-16007-7

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