Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis

Keratoconus is a common ectatic corneal disorder in adolescents and young adults that can lead to progressive visual impairment or even legal blindness. Despite the high prevalence, its etiology is not fully understood. In this study, we performed single-cell RNA sequencing (scRNA-Seq) analysis on 3...

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Detalles Bibliográficos
Autores principales: Dou, Shengqian, Wang, Qun, Zhang, Bin, Wei, Chao, Wang, Huijin, Liu, Ting, Duan, Haoyun, Jiang, Hui, Liu, Mingna, Qi, Xiaolin, Zhou, Qingjun, Xie, Lixin, Shi, Weiyun, Gao, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276680/
https://www.ncbi.nlm.nih.gov/pubmed/35821117
http://dx.doi.org/10.1038/s41421-022-00397-z

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