Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset hereditary neurodegenerative disease caused by the expansions of CAG repeats in the androgen receptor (AR) gene. Androgen-dependent nuclear accumulation of pathogenic AR protein causes degeneration of lower motor neurons, leading to progres...

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Detalles Bibliográficos
Autores principales: Ogura, Yosuke, Sahashi, Kentaro, Hirunagi, Tomoki, Iida, Madoka, Miyata, Takaki, Katsuno, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276699/
https://www.ncbi.nlm.nih.gov/pubmed/35821212
http://dx.doi.org/10.1038/s41419-022-05001-6

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