Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms

BACKGROUND: Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially doubling 5-year event-free survival if tumour necrosis can be stimulated. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) enhances OS survival in part through up...

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Detalles Bibliográficos
Autores principales: Pan, Simin, Cesarek, Michael, Godoy, Carla, Co, Cynthia M., Schindler, Catherine, Padilla, Kelbi, Haskell, Andrew, Barreda, Heather, Story, Christopher, Poole, Roy, Dabney, Alan, Gregory, Carl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276700/
https://www.ncbi.nlm.nih.gov/pubmed/35277659
http://dx.doi.org/10.1038/s41416-022-01764-z

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