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Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma
The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n = 30) or glaucoma (n = 68) were examined with optical coherence tomography (OCT) and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276731/ https://www.ncbi.nlm.nih.gov/pubmed/35821224 http://dx.doi.org/10.1038/s41598-022-15401-5 |
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author | Lommatzsch, Claudia Rothaus, Kai Schopmeyer, Lasse Feldmann, Maria Bauer, Dirk Grisanti, Swaantje Heinz, Carsten Kasper, Maren |
author_facet | Lommatzsch, Claudia Rothaus, Kai Schopmeyer, Lasse Feldmann, Maria Bauer, Dirk Grisanti, Swaantje Heinz, Carsten Kasper, Maren |
author_sort | Lommatzsch, Claudia |
collection | PubMed |
description | The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n = 30) or glaucoma (n = 68) were examined with optical coherence tomography (OCT) and OCT-angiography (OCT-A; AngioVue™-RTVue-XR; Optovue, Fremont, California, USA). The peripapillary and the macular vessel density (VD) values were measured. Inferior and superior retinal nerve fibre layer (RNFL) thickness loss was used for further OCT staging. Aqueous humour of the examined eye and plasma were sampled during cataract or glaucoma surgery and analysed by means of ELISA to determine their ET-1 level. Glaucoma eyes are characterised by reductions in RNFL thickness and VD that correlate significantly with the OCT GSS score. Peripheral and ocular ET-1 level were significantly elevated in patients with glaucoma and correlate positively with the OCT-GSS score of the entire study population. Peripapillary and macula VD of glaucoma patients correlates negatively with plasma ET-1 levels. Multivariable analysis showed a subordinate role of intraocular pressure predictive factor for impaired retinal blood flow compared with plasma ET-1 level in glaucoma. Peripheral ET-1 level serves as risk factor for detection of ocular blood flow changes in the optic nerve head region of glaucomatous eyes. |
format | Online Article Text |
id | pubmed-9276731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92767312022-07-14 Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma Lommatzsch, Claudia Rothaus, Kai Schopmeyer, Lasse Feldmann, Maria Bauer, Dirk Grisanti, Swaantje Heinz, Carsten Kasper, Maren Sci Rep Article The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration of ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes of patients with cataract (n = 30) or glaucoma (n = 68) were examined with optical coherence tomography (OCT) and OCT-angiography (OCT-A; AngioVue™-RTVue-XR; Optovue, Fremont, California, USA). The peripapillary and the macular vessel density (VD) values were measured. Inferior and superior retinal nerve fibre layer (RNFL) thickness loss was used for further OCT staging. Aqueous humour of the examined eye and plasma were sampled during cataract or glaucoma surgery and analysed by means of ELISA to determine their ET-1 level. Glaucoma eyes are characterised by reductions in RNFL thickness and VD that correlate significantly with the OCT GSS score. Peripheral and ocular ET-1 level were significantly elevated in patients with glaucoma and correlate positively with the OCT-GSS score of the entire study population. Peripapillary and macula VD of glaucoma patients correlates negatively with plasma ET-1 levels. Multivariable analysis showed a subordinate role of intraocular pressure predictive factor for impaired retinal blood flow compared with plasma ET-1 level in glaucoma. Peripheral ET-1 level serves as risk factor for detection of ocular blood flow changes in the optic nerve head region of glaucomatous eyes. Nature Publishing Group UK 2022-07-12 /pmc/articles/PMC9276731/ /pubmed/35821224 http://dx.doi.org/10.1038/s41598-022-15401-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lommatzsch, Claudia Rothaus, Kai Schopmeyer, Lasse Feldmann, Maria Bauer, Dirk Grisanti, Swaantje Heinz, Carsten Kasper, Maren Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
title | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
title_full | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
title_fullStr | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
title_full_unstemmed | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
title_short | Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma |
title_sort | elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by oct-a in glaucoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276731/ https://www.ncbi.nlm.nih.gov/pubmed/35821224 http://dx.doi.org/10.1038/s41598-022-15401-5 |
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