Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury

Apoptosis is a critical event in the pathogenesis of lung ischemia/reperfusion (I/R) injury. Sirtuin 3 (SIRT3), an important deacetylase predominantly localized in mitochondria, regulates diverse physiological processes, including apoptosis. However, the detailed mechanisms by which SIRT3 regulates...

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Detalles Bibliográficos
Autores principales: Zhao, Jing, Wang, Guorong, Han, Kaitao, Wang, Yang, Wang, Lin, Gao, Jinxia, Zhao, Sen, Wang, Gang, Chen, Shengyang, Luo, An, Wu, Jianlin, Wang, Guangzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276754/
https://www.ncbi.nlm.nih.gov/pubmed/35821123
http://dx.doi.org/10.1038/s41419-022-05051-w

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