Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics

Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Notch response depend on the posttranslational modifications (PTMs) of the activated NOTCH receptor – the NOTCH intracellular domain (NICD). In normoxic...

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Detalles Bibliográficos
Autores principales: Ferrante, Francesca, Giaimo, Benedetto Daniele, Friedrich, Tobias, Sugino, Toshiya, Mertens, Daniel, Kugler, Sabrina, Gahr, Bernd Martin, Just, Steffen, Pan, Leiling, Bartkuhn, Marek, Potente, Michael, Oswald, Franz, Borggrefe, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276811/
https://www.ncbi.nlm.nih.gov/pubmed/35821235
http://dx.doi.org/10.1038/s41419-022-05052-9

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