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Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series

INTRODUCTION: Lichen planopilaris (LPP) is characterized by chronic scarring alopecia that is progressive and typically refractory to therapy. Current drug treatments are suboptimal and not applicable for long-term use because of the high potential for adverse effects, warranting safer and more effe...

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Autores principales: Umar, Sanusi, Kan, Petrina, Carter, Marissa J., Shitabata, Paul, Novosilska, Myroslava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276860/
https://www.ncbi.nlm.nih.gov/pubmed/35674981
http://dx.doi.org/10.1007/s13555-022-00749-3
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author Umar, Sanusi
Kan, Petrina
Carter, Marissa J.
Shitabata, Paul
Novosilska, Myroslava
author_facet Umar, Sanusi
Kan, Petrina
Carter, Marissa J.
Shitabata, Paul
Novosilska, Myroslava
author_sort Umar, Sanusi
collection PubMed
description INTRODUCTION: Lichen planopilaris (LPP) is characterized by chronic scarring alopecia that is progressive and typically refractory to therapy. Current drug treatments are suboptimal and not applicable for long-term use because of the high potential for adverse effects, warranting safer and more effective treatment alternatives. METHODS: Based on our previous success in treating a patient with central centrifugal cicatricial alopecia using a topical botanical formulation (Gashee), we reviewed records of four patients with biopsy-proven LPP treated with the topical formulation alone or in combination with its oral preparation. Three patients had failed previous treatment with intralesional steroid injections, topical minoxidil, tacrolimus, and clobetasol. Physical examination and photographic documentation were also used as outcome measures. Treatment duration with the botanical formulations ranged from 6 weeks to 9.5 months. RESULTS: All patients showed overall improvement in surrogate indicators of LPP activity as evidenced by the disappearance of symptoms (pruritus, tenderness, scalp irritation, and hair shedding), improvement in hair growth, and reduction in redness. All reported a high satisfaction level and no adverse effects. CONCLUSIONS: Patients with treatment-refractory LPP responded to a novel botanical treatment. To the best of our knowledge, this is the first published report of LPP responding to a plant-based natural treatment. Further evaluation of this treatment in a controlled trial with a larger number of patients is warranted.
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spelling pubmed-92768602022-07-14 Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series Umar, Sanusi Kan, Petrina Carter, Marissa J. Shitabata, Paul Novosilska, Myroslava Dermatol Ther (Heidelb) Case Series INTRODUCTION: Lichen planopilaris (LPP) is characterized by chronic scarring alopecia that is progressive and typically refractory to therapy. Current drug treatments are suboptimal and not applicable for long-term use because of the high potential for adverse effects, warranting safer and more effective treatment alternatives. METHODS: Based on our previous success in treating a patient with central centrifugal cicatricial alopecia using a topical botanical formulation (Gashee), we reviewed records of four patients with biopsy-proven LPP treated with the topical formulation alone or in combination with its oral preparation. Three patients had failed previous treatment with intralesional steroid injections, topical minoxidil, tacrolimus, and clobetasol. Physical examination and photographic documentation were also used as outcome measures. Treatment duration with the botanical formulations ranged from 6 weeks to 9.5 months. RESULTS: All patients showed overall improvement in surrogate indicators of LPP activity as evidenced by the disappearance of symptoms (pruritus, tenderness, scalp irritation, and hair shedding), improvement in hair growth, and reduction in redness. All reported a high satisfaction level and no adverse effects. CONCLUSIONS: Patients with treatment-refractory LPP responded to a novel botanical treatment. To the best of our knowledge, this is the first published report of LPP responding to a plant-based natural treatment. Further evaluation of this treatment in a controlled trial with a larger number of patients is warranted. Springer Healthcare 2022-06-08 /pmc/articles/PMC9276860/ /pubmed/35674981 http://dx.doi.org/10.1007/s13555-022-00749-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Series
Umar, Sanusi
Kan, Petrina
Carter, Marissa J.
Shitabata, Paul
Novosilska, Myroslava
Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
title Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
title_full Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
title_fullStr Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
title_full_unstemmed Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
title_short Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
title_sort lichen planopilaris responsive to a novel phytoactive botanical treatment: a case series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276860/
https://www.ncbi.nlm.nih.gov/pubmed/35674981
http://dx.doi.org/10.1007/s13555-022-00749-3
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