LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer

Pancreatic cancer is the leading cause of cancer-related mortality because of tumor metastasis. Activation of the epithelial-to-mesenchymal transition (EMT) pathway has been confirmed to be an important driver of pancreatic cancer progression from initiation to metastasis. Long noncoding RNAs (lncRN...

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Autores principales: Ma, Yan, Di, Yang, Li, Qiuyue, Zhan, Qilin, He, Xiaomeng, Liu, Shanshan, Zou, Heng, Corpe, Christopher, Chen, Litian, Wang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276894/
https://www.ncbi.nlm.nih.gov/pubmed/35819532
http://dx.doi.org/10.1007/s12672-022-00522-0
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author Ma, Yan
Di, Yang
Li, Qiuyue
Zhan, Qilin
He, Xiaomeng
Liu, Shanshan
Zou, Heng
Corpe, Christopher
Chen, Litian
Wang, Jin
author_facet Ma, Yan
Di, Yang
Li, Qiuyue
Zhan, Qilin
He, Xiaomeng
Liu, Shanshan
Zou, Heng
Corpe, Christopher
Chen, Litian
Wang, Jin
author_sort Ma, Yan
collection PubMed
description Pancreatic cancer is the leading cause of cancer-related mortality because of tumor metastasis. Activation of the epithelial-to-mesenchymal transition (EMT) pathway has been confirmed to be an important driver of pancreatic cancer progression from initiation to metastasis. Long noncoding RNAs (lncRNAs) have been reported to exert essential physiological functions in pancreatic cancer progression by regulating the EMT program. In this review, we have summarized the role of EMT-related lncRNAs in human pancreatic cancer and the potential molecular mechanisms by which lncRNAs can be vital epigenetic regulators of epithelial to mesenchymal transition. Specifically, EMT-activating transcription factors (EMT-TFs) regulate EMT via TGF-β/Smad, Wnt/β-catenin, and JAK/STAT pathways. In addition, the interaction between lncRNAs and HIF-1α and m6A RNA methylation also have an impact on tumor metastasis and EMT in pancreatic cancer. This review will provide insights into lncRNAs as promising biomarkers for tumor metastasis and potential therapeutic strategies for pancreatic cancer.
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spelling pubmed-92768942022-07-14 LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer Ma, Yan Di, Yang Li, Qiuyue Zhan, Qilin He, Xiaomeng Liu, Shanshan Zou, Heng Corpe, Christopher Chen, Litian Wang, Jin Discov Oncol Review Pancreatic cancer is the leading cause of cancer-related mortality because of tumor metastasis. Activation of the epithelial-to-mesenchymal transition (EMT) pathway has been confirmed to be an important driver of pancreatic cancer progression from initiation to metastasis. Long noncoding RNAs (lncRNAs) have been reported to exert essential physiological functions in pancreatic cancer progression by regulating the EMT program. In this review, we have summarized the role of EMT-related lncRNAs in human pancreatic cancer and the potential molecular mechanisms by which lncRNAs can be vital epigenetic regulators of epithelial to mesenchymal transition. Specifically, EMT-activating transcription factors (EMT-TFs) regulate EMT via TGF-β/Smad, Wnt/β-catenin, and JAK/STAT pathways. In addition, the interaction between lncRNAs and HIF-1α and m6A RNA methylation also have an impact on tumor metastasis and EMT in pancreatic cancer. This review will provide insights into lncRNAs as promising biomarkers for tumor metastasis and potential therapeutic strategies for pancreatic cancer. Springer US 2022-07-11 /pmc/articles/PMC9276894/ /pubmed/35819532 http://dx.doi.org/10.1007/s12672-022-00522-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ma, Yan
Di, Yang
Li, Qiuyue
Zhan, Qilin
He, Xiaomeng
Liu, Shanshan
Zou, Heng
Corpe, Christopher
Chen, Litian
Wang, Jin
LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
title LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
title_full LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
title_fullStr LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
title_full_unstemmed LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
title_short LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
title_sort lncrnas as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276894/
https://www.ncbi.nlm.nih.gov/pubmed/35819532
http://dx.doi.org/10.1007/s12672-022-00522-0
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