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Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study

Metabolic syndrome is a condition characterized by a clustering of metabolic abnormalities associated with an increased risk of type 2 diabetes and cardiovascular disease. An impaired insulin-stimulated myocardial glucose metabolism has been shown to be a risk factor for the development of cardiovas...

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Autores principales: Succurro, Elena, Vizza, Patrizia, Papa, Annalisa, Cicone, Francesco, Monea, Giuseppe, Tradigo, Giuseppe, Fiorentino, Teresa Vanessa, Perticone, Maria, Guzzi, Pietro Hiram, Sciacqua, Angela, Andreozzi, Francesco, Veltri, Pierangelo, Cascini, Giuseppe Lucio, Sesti, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276995/
https://www.ncbi.nlm.nih.gov/pubmed/35845046
http://dx.doi.org/10.3389/fcvm.2022.924787
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author Succurro, Elena
Vizza, Patrizia
Papa, Annalisa
Cicone, Francesco
Monea, Giuseppe
Tradigo, Giuseppe
Fiorentino, Teresa Vanessa
Perticone, Maria
Guzzi, Pietro Hiram
Sciacqua, Angela
Andreozzi, Francesco
Veltri, Pierangelo
Cascini, Giuseppe Lucio
Sesti, Giorgio
author_facet Succurro, Elena
Vizza, Patrizia
Papa, Annalisa
Cicone, Francesco
Monea, Giuseppe
Tradigo, Giuseppe
Fiorentino, Teresa Vanessa
Perticone, Maria
Guzzi, Pietro Hiram
Sciacqua, Angela
Andreozzi, Francesco
Veltri, Pierangelo
Cascini, Giuseppe Lucio
Sesti, Giorgio
author_sort Succurro, Elena
collection PubMed
description Metabolic syndrome is a condition characterized by a clustering of metabolic abnormalities associated with an increased risk of type 2 diabetes and cardiovascular disease. An impaired insulin-stimulated myocardial glucose metabolism has been shown to be a risk factor for the development of cardiovascular disease in patients with type 2 diabetes. Whether cardiac insulin resistance occurs in subjects with metabolic syndrome remains uncertain. To investigate this issue, we evaluated myocardial glucose metabolic rate using cardiac dynamic (18)F-FDG-PET combined with euglycemic-hyperinsulinemic clamp in three groups: a group of normal glucose tolerant individuals without metabolic syndrome (n = 10), a group of individuals with type 2 diabetes and metabolic syndrome (n = 19), and a group of subjects with type 2 diabetes without metabolic syndrome (n = 6). After adjusting for age and gender, individuals with type 2 diabetes and metabolic syndrome exhibited a significant reduction in insulin-stimulated myocardial glucose metabolic rate (10.5 ± 9.04 μmol/min/100 g) as compared with both control subjects (32.9 ± 9.7 μmol/min/100 g; P < 0.0001) and subjects with type 2 diabetes without metabolic syndrome (25.15 ± 4.92 μmol/min/100 g; P = 0.01). Conversely, as compared with control subjects (13.01 ± 8.53 mg/min x Kg FFM), both diabetic individuals with metabolic syndrome (3.06 ± 1.7 mg/min × Kg FFM, P = 0.008) and those without metabolic syndrome (2.91 ± 1.54 mg/min × Kg FFM, P = 0.01) exhibited a significant reduction in whole-body insulin-stimulated glucose disposal, while no difference was observed between the 2 groups of subjects with type 2 diabetes with or without metabolic syndrome. Univariate correlations showed that myocardial glucose metabolism was positively correlated with insulin-stimulated glucose disposal (r = 0.488, P = 0.003), and negatively correlated with the presence of metabolic syndrome (r = −0.743, P < 0.0001) and with its individual components. In conclusion, our data suggest that an impaired myocardial glucose metabolism may represent an early cardio-metabolic defect in individuals with the coexistence of type 2 diabetes and metabolic syndrome, regardless of whole-body insulin resistance.
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spelling pubmed-92769952022-07-14 Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study Succurro, Elena Vizza, Patrizia Papa, Annalisa Cicone, Francesco Monea, Giuseppe Tradigo, Giuseppe Fiorentino, Teresa Vanessa Perticone, Maria Guzzi, Pietro Hiram Sciacqua, Angela Andreozzi, Francesco Veltri, Pierangelo Cascini, Giuseppe Lucio Sesti, Giorgio Front Cardiovasc Med Cardiovascular Medicine Metabolic syndrome is a condition characterized by a clustering of metabolic abnormalities associated with an increased risk of type 2 diabetes and cardiovascular disease. An impaired insulin-stimulated myocardial glucose metabolism has been shown to be a risk factor for the development of cardiovascular disease in patients with type 2 diabetes. Whether cardiac insulin resistance occurs in subjects with metabolic syndrome remains uncertain. To investigate this issue, we evaluated myocardial glucose metabolic rate using cardiac dynamic (18)F-FDG-PET combined with euglycemic-hyperinsulinemic clamp in three groups: a group of normal glucose tolerant individuals without metabolic syndrome (n = 10), a group of individuals with type 2 diabetes and metabolic syndrome (n = 19), and a group of subjects with type 2 diabetes without metabolic syndrome (n = 6). After adjusting for age and gender, individuals with type 2 diabetes and metabolic syndrome exhibited a significant reduction in insulin-stimulated myocardial glucose metabolic rate (10.5 ± 9.04 μmol/min/100 g) as compared with both control subjects (32.9 ± 9.7 μmol/min/100 g; P < 0.0001) and subjects with type 2 diabetes without metabolic syndrome (25.15 ± 4.92 μmol/min/100 g; P = 0.01). Conversely, as compared with control subjects (13.01 ± 8.53 mg/min x Kg FFM), both diabetic individuals with metabolic syndrome (3.06 ± 1.7 mg/min × Kg FFM, P = 0.008) and those without metabolic syndrome (2.91 ± 1.54 mg/min × Kg FFM, P = 0.01) exhibited a significant reduction in whole-body insulin-stimulated glucose disposal, while no difference was observed between the 2 groups of subjects with type 2 diabetes with or without metabolic syndrome. Univariate correlations showed that myocardial glucose metabolism was positively correlated with insulin-stimulated glucose disposal (r = 0.488, P = 0.003), and negatively correlated with the presence of metabolic syndrome (r = −0.743, P < 0.0001) and with its individual components. In conclusion, our data suggest that an impaired myocardial glucose metabolism may represent an early cardio-metabolic defect in individuals with the coexistence of type 2 diabetes and metabolic syndrome, regardless of whole-body insulin resistance. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9276995/ /pubmed/35845046 http://dx.doi.org/10.3389/fcvm.2022.924787 Text en Copyright © 2022 Succurro, Vizza, Papa, Cicone, Monea, Tradigo, Fiorentino, Perticone, Guzzi, Sciacqua, Andreozzi, Veltri, Cascini and Sesti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Succurro, Elena
Vizza, Patrizia
Papa, Annalisa
Cicone, Francesco
Monea, Giuseppe
Tradigo, Giuseppe
Fiorentino, Teresa Vanessa
Perticone, Maria
Guzzi, Pietro Hiram
Sciacqua, Angela
Andreozzi, Francesco
Veltri, Pierangelo
Cascini, Giuseppe Lucio
Sesti, Giorgio
Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study
title Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study
title_full Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study
title_fullStr Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study
title_full_unstemmed Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study
title_short Metabolic Syndrome Is Associated With Impaired Insulin-Stimulated Myocardial Glucose Metabolic Rate in Individuals With Type 2 Diabetes: A Cardiac Dynamic (18)F-FDG-PET Study
title_sort metabolic syndrome is associated with impaired insulin-stimulated myocardial glucose metabolic rate in individuals with type 2 diabetes: a cardiac dynamic (18)f-fdg-pet study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276995/
https://www.ncbi.nlm.nih.gov/pubmed/35845046
http://dx.doi.org/10.3389/fcvm.2022.924787
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