HP-NAP of Helicobacter pylori: The Power of the Immunomodulation

The miniferritin HP-NAP of Helicobacter pylori was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 respons...

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Autores principales: Codolo, Gaia, Coletta, Sara, D’Elios, Mario Milco, de Bernard, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277015/
https://www.ncbi.nlm.nih.gov/pubmed/35844568
http://dx.doi.org/10.3389/fimmu.2022.944139
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author Codolo, Gaia
Coletta, Sara
D’Elios, Mario Milco
de Bernard, Marina
author_facet Codolo, Gaia
Coletta, Sara
D’Elios, Mario Milco
de Bernard, Marina
author_sort Codolo, Gaia
collection PubMed
description The miniferritin HP-NAP of Helicobacter pylori was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 responses and revert the immune suppressive profile of macrophages. In this review, we discuss the immune modulating properties of the protein regarding the H. pylori infection and the evidence that support the potential clinical application of HP-NAP in allergy and cancer immunotherapy.
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spelling pubmed-92770152022-07-14 HP-NAP of Helicobacter pylori: The Power of the Immunomodulation Codolo, Gaia Coletta, Sara D’Elios, Mario Milco de Bernard, Marina Front Immunol Immunology The miniferritin HP-NAP of Helicobacter pylori was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 responses and revert the immune suppressive profile of macrophages. In this review, we discuss the immune modulating properties of the protein regarding the H. pylori infection and the evidence that support the potential clinical application of HP-NAP in allergy and cancer immunotherapy. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9277015/ /pubmed/35844568 http://dx.doi.org/10.3389/fimmu.2022.944139 Text en Copyright © 2022 Codolo, Coletta, D’Elios and de Bernard https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Codolo, Gaia
Coletta, Sara
D’Elios, Mario Milco
de Bernard, Marina
HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
title HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
title_full HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
title_fullStr HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
title_full_unstemmed HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
title_short HP-NAP of Helicobacter pylori: The Power of the Immunomodulation
title_sort hp-nap of helicobacter pylori: the power of the immunomodulation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277015/
https://www.ncbi.nlm.nih.gov/pubmed/35844568
http://dx.doi.org/10.3389/fimmu.2022.944139
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AT deliosmariomilco hpnapofhelicobacterpylorithepoweroftheimmunomodulation
AT debernardmarina hpnapofhelicobacterpylorithepoweroftheimmunomodulation

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