Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design

The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects. The favorable chemical, physical, and nuclear characteristics of fluorine-18 (97% β(+) decay, 109.8 min half-life,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yunze, Lin, Qingyu, Shi, Hongcheng, Cheng, Dengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277085/
https://www.ncbi.nlm.nih.gov/pubmed/35844642
http://dx.doi.org/10.3389/fchem.2022.884517
_version_ 1784745874817024000
author Wang, Yunze
Lin, Qingyu
Shi, Hongcheng
Cheng, Dengfeng
author_facet Wang, Yunze
Lin, Qingyu
Shi, Hongcheng
Cheng, Dengfeng
author_sort Wang, Yunze
collection PubMed
description The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects. The favorable chemical, physical, and nuclear characteristics of fluorine-18 (97% β(+) decay, 109.8 min half-life, 635 keV positron energy) make it an attractive nuclide for labeling and molecular imaging. It stands that 2-[(18)F]fluoro-2-deoxy-D-glucose ([(18)F]FDG) is the most popular PET tracer. Besides that, a significantly abundant proportion of PET probes in clinical use or under development contain a fluorine or fluoroalkyl substituent group. For the reasons given above, (18)F-labeled radiotracer design has become a hot topic in radiochemistry and radiopharmaceutics. Over the past decades, we have witnessed a rapid growth in (18)F-labeling methods owing to the development of new reagents and catalysts. This review aims to provide an overview of strategies in radiosynthesis of [(18)F]fluorine-containing moieties with nucleophilic [(18)F]fluorides since 2015.
format Online
Article
Text
id pubmed-9277085
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92770852022-07-14 Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design Wang, Yunze Lin, Qingyu Shi, Hongcheng Cheng, Dengfeng Front Chem Chemistry The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects. The favorable chemical, physical, and nuclear characteristics of fluorine-18 (97% β(+) decay, 109.8 min half-life, 635 keV positron energy) make it an attractive nuclide for labeling and molecular imaging. It stands that 2-[(18)F]fluoro-2-deoxy-D-glucose ([(18)F]FDG) is the most popular PET tracer. Besides that, a significantly abundant proportion of PET probes in clinical use or under development contain a fluorine or fluoroalkyl substituent group. For the reasons given above, (18)F-labeled radiotracer design has become a hot topic in radiochemistry and radiopharmaceutics. Over the past decades, we have witnessed a rapid growth in (18)F-labeling methods owing to the development of new reagents and catalysts. This review aims to provide an overview of strategies in radiosynthesis of [(18)F]fluorine-containing moieties with nucleophilic [(18)F]fluorides since 2015. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9277085/ /pubmed/35844642 http://dx.doi.org/10.3389/fchem.2022.884517 Text en Copyright © 2022 Wang, Lin, Shi and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Yunze
Lin, Qingyu
Shi, Hongcheng
Cheng, Dengfeng
Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
title Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
title_full Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
title_fullStr Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
title_full_unstemmed Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
title_short Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
title_sort fluorine-18: radiochemistry and target-specific pet molecular probes design
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277085/
https://www.ncbi.nlm.nih.gov/pubmed/35844642
http://dx.doi.org/10.3389/fchem.2022.884517
work_keys_str_mv AT wangyunze fluorine18radiochemistryandtargetspecificpetmolecularprobesdesign
AT linqingyu fluorine18radiochemistryandtargetspecificpetmolecularprobesdesign
AT shihongcheng fluorine18radiochemistryandtargetspecificpetmolecularprobesdesign
AT chengdengfeng fluorine18radiochemistryandtargetspecificpetmolecularprobesdesign

Ejemplares similares