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Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators
Adult neural stem and progenitor cells (aNSPCs) persist lifelong in teleost models in diverse stem cell niches of the brain and spinal cord. Fish maintain developmental stem cell populations throughout life, including both neuro-epithelial cells (NECs) and radial-glial cells (RGCs). Within stem cell...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277145/ https://www.ncbi.nlm.nih.gov/pubmed/35846369 http://dx.doi.org/10.3389/fcell.2022.941893 |
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author | Caron, Aurélien Trzuskot, Lidia Lindsey, Benjamin W. |
author_facet | Caron, Aurélien Trzuskot, Lidia Lindsey, Benjamin W. |
author_sort | Caron, Aurélien |
collection | PubMed |
description | Adult neural stem and progenitor cells (aNSPCs) persist lifelong in teleost models in diverse stem cell niches of the brain and spinal cord. Fish maintain developmental stem cell populations throughout life, including both neuro-epithelial cells (NECs) and radial-glial cells (RGCs). Within stem cell domains of the brain, RGCs persist in a cycling or quiescent state, whereas NECs continuously divide. Heterogeneous populations of RGCs also sit adjacent the central canal of the spinal cord, showing infrequent proliferative activity under homeostasis. With the rise of the zebrafish (Danio rerio) model to study adult neurogenesis and neuroregeneration in the central nervous system (CNS), it has become evident that aNSPC proliferation is regulated by a wealth of stimuli that may be coupled with biological function. Growing evidence suggests that aNSPCs are sensitive to environmental cues, social interactions, nutrient availability, and neurotrauma for example, and that distinct stem and progenitor cell populations alter their cell cycle activity accordingly. Such stimuli appear to act as triggers to either turn on normally dormant aNSPCs or modulate constitutive rates of niche-specific cell cycle behaviour. Defining the various forms of stimuli that influence RGC and NEC proliferation, and identifying the molecular regulators responsible, will strengthen our understanding of the connection between aNSPC activity and their biological significance. In this review, we aim to bring together the current state of knowledge on aNSPCs from studies investigating the zebrafish CNS, while highlighting emerging cell cycle regulators and outstanding questions that will help to advance this fascinating field of stem cell biology. |
format | Online Article Text |
id | pubmed-9277145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92771452022-07-14 Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators Caron, Aurélien Trzuskot, Lidia Lindsey, Benjamin W. Front Cell Dev Biol Cell and Developmental Biology Adult neural stem and progenitor cells (aNSPCs) persist lifelong in teleost models in diverse stem cell niches of the brain and spinal cord. Fish maintain developmental stem cell populations throughout life, including both neuro-epithelial cells (NECs) and radial-glial cells (RGCs). Within stem cell domains of the brain, RGCs persist in a cycling or quiescent state, whereas NECs continuously divide. Heterogeneous populations of RGCs also sit adjacent the central canal of the spinal cord, showing infrequent proliferative activity under homeostasis. With the rise of the zebrafish (Danio rerio) model to study adult neurogenesis and neuroregeneration in the central nervous system (CNS), it has become evident that aNSPC proliferation is regulated by a wealth of stimuli that may be coupled with biological function. Growing evidence suggests that aNSPCs are sensitive to environmental cues, social interactions, nutrient availability, and neurotrauma for example, and that distinct stem and progenitor cell populations alter their cell cycle activity accordingly. Such stimuli appear to act as triggers to either turn on normally dormant aNSPCs or modulate constitutive rates of niche-specific cell cycle behaviour. Defining the various forms of stimuli that influence RGC and NEC proliferation, and identifying the molecular regulators responsible, will strengthen our understanding of the connection between aNSPC activity and their biological significance. In this review, we aim to bring together the current state of knowledge on aNSPCs from studies investigating the zebrafish CNS, while highlighting emerging cell cycle regulators and outstanding questions that will help to advance this fascinating field of stem cell biology. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9277145/ /pubmed/35846369 http://dx.doi.org/10.3389/fcell.2022.941893 Text en Copyright © 2022 Caron, Trzuskot and Lindsey. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Caron, Aurélien Trzuskot, Lidia Lindsey, Benjamin W. Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
title | Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
title_full | Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
title_fullStr | Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
title_full_unstemmed | Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
title_short | Uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
title_sort | uncovering the spectrum of adult zebrafish neural stem cell cycle regulators |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277145/ https://www.ncbi.nlm.nih.gov/pubmed/35846369 http://dx.doi.org/10.3389/fcell.2022.941893 |
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