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Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training

Angiotensin‐converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well‐controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptati...

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Autores principales: Sjúrðarson, Tórur, Bejder, Jacob, Breenfeldt Andersen, Andreas, Bonne, Thomas, Kyhl, Kasper, Róin, Tóra, Patursson, Poula, Oddmarsdóttir Gregersen, Noomi, Skoradal, May‐Britt, Schliemann, Michael, Lindegaard, Malte, Weihe, Pál, Mohr, Magni, Nordsborg, Nikolai B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277514/
https://www.ncbi.nlm.nih.gov/pubmed/35822425
http://dx.doi.org/10.14814/phy2.15382
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author Sjúrðarson, Tórur
Bejder, Jacob
Breenfeldt Andersen, Andreas
Bonne, Thomas
Kyhl, Kasper
Róin, Tóra
Patursson, Poula
Oddmarsdóttir Gregersen, Noomi
Skoradal, May‐Britt
Schliemann, Michael
Lindegaard, Malte
Weihe, Pál
Mohr, Magni
Nordsborg, Nikolai B.
author_facet Sjúrðarson, Tórur
Bejder, Jacob
Breenfeldt Andersen, Andreas
Bonne, Thomas
Kyhl, Kasper
Róin, Tóra
Patursson, Poula
Oddmarsdóttir Gregersen, Noomi
Skoradal, May‐Britt
Schliemann, Michael
Lindegaard, Malte
Weihe, Pál
Mohr, Magni
Nordsborg, Nikolai B.
author_sort Sjúrðarson, Tórur
collection PubMed
description Angiotensin‐converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well‐controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double‐blind, placebo‐controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by −5.5 [−8.4; −2.6] mmHg in ACE(i), whereas the 0.7 [−2.0; 3.5] mmHg fluctuation in PLA was non‐significant. Maximal oxygen uptake increased (p < 0.001) irrespective of ACE inhibitor treatment by 13 [8; 17] % in ACE(i) and 13 [9; 17] % in PLA. In addition, skeletal muscle endurance increased (p < 0.001) to a similar extent in both groups, with magnitudes of 82 [55; 113] % in ACE(i) and 74 [48; 105] % in PLA. In contrast, left atrial volume decreased (p < 0.05) by −9 [−16; −2] % in ACE(i), but increased (p < 0.01) by 14 [5; 23] % in PLA. Total hemoglobin mass was reduced (p < 0.01) by −3 [−6; −1] % in ACE(i), while a non‐significant numeric increase of 2 [−0.4; 4] % existed in PLA. The lean mass remained constant in ACE(i) but increased (p < 0.001) by 3 [2; 4] % in PLA. In healthy middle‐aged adults, 8 weeks of high‐intensity exercise training increases maximal oxygen uptake and skeletal muscle endurance irrespective of ACE inhibitor treatment. However, ACE inhibitor treatment counteracts exercise training‐induced increases in lean mass and left atrial volume. ACE inhibitor treatment compromises total hemoglobin mass.
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spelling pubmed-92775142022-07-15 Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training Sjúrðarson, Tórur Bejder, Jacob Breenfeldt Andersen, Andreas Bonne, Thomas Kyhl, Kasper Róin, Tóra Patursson, Poula Oddmarsdóttir Gregersen, Noomi Skoradal, May‐Britt Schliemann, Michael Lindegaard, Malte Weihe, Pál Mohr, Magni Nordsborg, Nikolai B. Physiol Rep Original Articles Angiotensin‐converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well‐controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double‐blind, placebo‐controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by −5.5 [−8.4; −2.6] mmHg in ACE(i), whereas the 0.7 [−2.0; 3.5] mmHg fluctuation in PLA was non‐significant. Maximal oxygen uptake increased (p < 0.001) irrespective of ACE inhibitor treatment by 13 [8; 17] % in ACE(i) and 13 [9; 17] % in PLA. In addition, skeletal muscle endurance increased (p < 0.001) to a similar extent in both groups, with magnitudes of 82 [55; 113] % in ACE(i) and 74 [48; 105] % in PLA. In contrast, left atrial volume decreased (p < 0.05) by −9 [−16; −2] % in ACE(i), but increased (p < 0.01) by 14 [5; 23] % in PLA. Total hemoglobin mass was reduced (p < 0.01) by −3 [−6; −1] % in ACE(i), while a non‐significant numeric increase of 2 [−0.4; 4] % existed in PLA. The lean mass remained constant in ACE(i) but increased (p < 0.001) by 3 [2; 4] % in PLA. In healthy middle‐aged adults, 8 weeks of high‐intensity exercise training increases maximal oxygen uptake and skeletal muscle endurance irrespective of ACE inhibitor treatment. However, ACE inhibitor treatment counteracts exercise training‐induced increases in lean mass and left atrial volume. ACE inhibitor treatment compromises total hemoglobin mass. John Wiley and Sons Inc. 2022-07-13 /pmc/articles/PMC9277514/ /pubmed/35822425 http://dx.doi.org/10.14814/phy2.15382 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Sjúrðarson, Tórur
Bejder, Jacob
Breenfeldt Andersen, Andreas
Bonne, Thomas
Kyhl, Kasper
Róin, Tóra
Patursson, Poula
Oddmarsdóttir Gregersen, Noomi
Skoradal, May‐Britt
Schliemann, Michael
Lindegaard, Malte
Weihe, Pál
Mohr, Magni
Nordsborg, Nikolai B.
Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
title Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
title_full Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
title_fullStr Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
title_full_unstemmed Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
title_short Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
title_sort effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277514/
https://www.ncbi.nlm.nih.gov/pubmed/35822425
http://dx.doi.org/10.14814/phy2.15382
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