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Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training
Angiotensin‐converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well‐controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptati...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277514/ https://www.ncbi.nlm.nih.gov/pubmed/35822425 http://dx.doi.org/10.14814/phy2.15382 |
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author | Sjúrðarson, Tórur Bejder, Jacob Breenfeldt Andersen, Andreas Bonne, Thomas Kyhl, Kasper Róin, Tóra Patursson, Poula Oddmarsdóttir Gregersen, Noomi Skoradal, May‐Britt Schliemann, Michael Lindegaard, Malte Weihe, Pál Mohr, Magni Nordsborg, Nikolai B. |
author_facet | Sjúrðarson, Tórur Bejder, Jacob Breenfeldt Andersen, Andreas Bonne, Thomas Kyhl, Kasper Róin, Tóra Patursson, Poula Oddmarsdóttir Gregersen, Noomi Skoradal, May‐Britt Schliemann, Michael Lindegaard, Malte Weihe, Pál Mohr, Magni Nordsborg, Nikolai B. |
author_sort | Sjúrðarson, Tórur |
collection | PubMed |
description | Angiotensin‐converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well‐controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double‐blind, placebo‐controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by −5.5 [−8.4; −2.6] mmHg in ACE(i), whereas the 0.7 [−2.0; 3.5] mmHg fluctuation in PLA was non‐significant. Maximal oxygen uptake increased (p < 0.001) irrespective of ACE inhibitor treatment by 13 [8; 17] % in ACE(i) and 13 [9; 17] % in PLA. In addition, skeletal muscle endurance increased (p < 0.001) to a similar extent in both groups, with magnitudes of 82 [55; 113] % in ACE(i) and 74 [48; 105] % in PLA. In contrast, left atrial volume decreased (p < 0.05) by −9 [−16; −2] % in ACE(i), but increased (p < 0.01) by 14 [5; 23] % in PLA. Total hemoglobin mass was reduced (p < 0.01) by −3 [−6; −1] % in ACE(i), while a non‐significant numeric increase of 2 [−0.4; 4] % existed in PLA. The lean mass remained constant in ACE(i) but increased (p < 0.001) by 3 [2; 4] % in PLA. In healthy middle‐aged adults, 8 weeks of high‐intensity exercise training increases maximal oxygen uptake and skeletal muscle endurance irrespective of ACE inhibitor treatment. However, ACE inhibitor treatment counteracts exercise training‐induced increases in lean mass and left atrial volume. ACE inhibitor treatment compromises total hemoglobin mass. |
format | Online Article Text |
id | pubmed-9277514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92775142022-07-15 Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training Sjúrðarson, Tórur Bejder, Jacob Breenfeldt Andersen, Andreas Bonne, Thomas Kyhl, Kasper Róin, Tóra Patursson, Poula Oddmarsdóttir Gregersen, Noomi Skoradal, May‐Britt Schliemann, Michael Lindegaard, Malte Weihe, Pál Mohr, Magni Nordsborg, Nikolai B. Physiol Rep Original Articles Angiotensin‐converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well‐controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double‐blind, placebo‐controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by −5.5 [−8.4; −2.6] mmHg in ACE(i), whereas the 0.7 [−2.0; 3.5] mmHg fluctuation in PLA was non‐significant. Maximal oxygen uptake increased (p < 0.001) irrespective of ACE inhibitor treatment by 13 [8; 17] % in ACE(i) and 13 [9; 17] % in PLA. In addition, skeletal muscle endurance increased (p < 0.001) to a similar extent in both groups, with magnitudes of 82 [55; 113] % in ACE(i) and 74 [48; 105] % in PLA. In contrast, left atrial volume decreased (p < 0.05) by −9 [−16; −2] % in ACE(i), but increased (p < 0.01) by 14 [5; 23] % in PLA. Total hemoglobin mass was reduced (p < 0.01) by −3 [−6; −1] % in ACE(i), while a non‐significant numeric increase of 2 [−0.4; 4] % existed in PLA. The lean mass remained constant in ACE(i) but increased (p < 0.001) by 3 [2; 4] % in PLA. In healthy middle‐aged adults, 8 weeks of high‐intensity exercise training increases maximal oxygen uptake and skeletal muscle endurance irrespective of ACE inhibitor treatment. However, ACE inhibitor treatment counteracts exercise training‐induced increases in lean mass and left atrial volume. ACE inhibitor treatment compromises total hemoglobin mass. John Wiley and Sons Inc. 2022-07-13 /pmc/articles/PMC9277514/ /pubmed/35822425 http://dx.doi.org/10.14814/phy2.15382 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Sjúrðarson, Tórur Bejder, Jacob Breenfeldt Andersen, Andreas Bonne, Thomas Kyhl, Kasper Róin, Tóra Patursson, Poula Oddmarsdóttir Gregersen, Noomi Skoradal, May‐Britt Schliemann, Michael Lindegaard, Malte Weihe, Pál Mohr, Magni Nordsborg, Nikolai B. Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
title | Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
title_full | Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
title_fullStr | Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
title_full_unstemmed | Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
title_short | Effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
title_sort | effect of angiotensin‐converting enzyme inhibition on cardiovascular adaptation to exercise training |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277514/ https://www.ncbi.nlm.nih.gov/pubmed/35822425 http://dx.doi.org/10.14814/phy2.15382 |
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