Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8(+) T Cells for Enhanced IFNγ Production by Metformin

Metformin (Met), a first-line drug for type 2 diabetes, lowers blood glucose levels by suppressing gluconeogenesis in the liver, presumably through the liver kinase B1-dependent activation of AMP-activated protein kinase (AMPK) after inhibiting respiratory chain complex I. Met is also implicated as...

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Detalles Bibliográficos
Autores principales: Chao, Ruoyu, Nishida, Mikako, Yamashita, Nahoko, Tokumasu, Miho, Zhao, Weiyang, Kudo, Ikuru, Udono, Heiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277540/
https://www.ncbi.nlm.nih.gov/pubmed/35844589
http://dx.doi.org/10.3389/fimmu.2022.864225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277540/
https://www.ncbi.nlm.nih.gov/pubmed/35844589
http://dx.doi.org/10.3389/fimmu.2022.864225

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