Cargando…

Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study

BACKGROUND: Best approaches for retaining research participants in Alzheimer’s disease cohort studies are understudied. OBJECTIVE: Using data from the National Alzheimer’s Coordinating Center Uniform Data Set, we evaluated the associations of unique strategies with participant retention across Alzhe...

Descripción completa

Detalles Bibliográficos
Autores principales: Salazar, Christian R., Ritchie, Marina, Gillen, Daniel L., Grill, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277665/
https://www.ncbi.nlm.nih.gov/pubmed/35491778
http://dx.doi.org/10.3233/JAD-215537
_version_ 1784746030564114432
author Salazar, Christian R.
Ritchie, Marina
Gillen, Daniel L.
Grill, Joshua D.
author_facet Salazar, Christian R.
Ritchie, Marina
Gillen, Daniel L.
Grill, Joshua D.
author_sort Salazar, Christian R.
collection PubMed
description BACKGROUND: Best approaches for retaining research participants in Alzheimer’s disease cohort studies are understudied. OBJECTIVE: Using data from the National Alzheimer’s Coordinating Center Uniform Data Set, we evaluated the associations of unique strategies with participant retention across Alzheimer’s Disease Research Centers and explored potential effect modification by race, ethnicity and diagnostic group. METHODS: We examined retention at the first follow-up visit among participants enrolled during 2015–2017. Structured surveys ascertained 95 retention tactics among 12 strategies. Strategy-specific summary scores were created based on the number of implemented tactics for each strategy and grouped into tertiles. Generalized estimating equations were constructed to evaluate associations between strategy scores and the odds of retention, controlling for age, sex, education, study partner type, marital status, visit length, battery length, diagnostic group, race and ethnicity. Separate models were stratified by race, ethnicity and diagnostic group. Effect modification was formally tested with interaction terms. RESULTS: Among 5,715 total participants enrolled, 4,515 were Non-Hispanic White (79%), 335 were Hispanic/Latino (6%), 651 were Non-Hispanic Black (11%), and 214 were Non-Hispanic Asian (4%). Compared to the lowest tertile of scores, the highest tertile of scores involving improvement in study personnel and communication of study requirements and details were associated with 61% higher odds of retention in fully adjusted models (adjusted Odds Ratios [aOR] = 1.61, 95% Confidence Interval [CI] = 1.05–2.47 and aOR = 1.55, 95% CI = 1.03–2.35, respectively). We did not find evidence for effect modification. CONCLUSION: In the setting of limited resources, specific retention strategies may be more valuable than others.
format Online
Article
Text
id pubmed-9277665
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-92776652022-07-25 Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study Salazar, Christian R. Ritchie, Marina Gillen, Daniel L. Grill, Joshua D. J Alzheimers Dis Research Article BACKGROUND: Best approaches for retaining research participants in Alzheimer’s disease cohort studies are understudied. OBJECTIVE: Using data from the National Alzheimer’s Coordinating Center Uniform Data Set, we evaluated the associations of unique strategies with participant retention across Alzheimer’s Disease Research Centers and explored potential effect modification by race, ethnicity and diagnostic group. METHODS: We examined retention at the first follow-up visit among participants enrolled during 2015–2017. Structured surveys ascertained 95 retention tactics among 12 strategies. Strategy-specific summary scores were created based on the number of implemented tactics for each strategy and grouped into tertiles. Generalized estimating equations were constructed to evaluate associations between strategy scores and the odds of retention, controlling for age, sex, education, study partner type, marital status, visit length, battery length, diagnostic group, race and ethnicity. Separate models were stratified by race, ethnicity and diagnostic group. Effect modification was formally tested with interaction terms. RESULTS: Among 5,715 total participants enrolled, 4,515 were Non-Hispanic White (79%), 335 were Hispanic/Latino (6%), 651 were Non-Hispanic Black (11%), and 214 were Non-Hispanic Asian (4%). Compared to the lowest tertile of scores, the highest tertile of scores involving improvement in study personnel and communication of study requirements and details were associated with 61% higher odds of retention in fully adjusted models (adjusted Odds Ratios [aOR] = 1.61, 95% Confidence Interval [CI] = 1.05–2.47 and aOR = 1.55, 95% CI = 1.03–2.35, respectively). We did not find evidence for effect modification. CONCLUSION: In the setting of limited resources, specific retention strategies may be more valuable than others. IOS Press 2022-06-14 /pmc/articles/PMC9277665/ /pubmed/35491778 http://dx.doi.org/10.3233/JAD-215537 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salazar, Christian R.
Ritchie, Marina
Gillen, Daniel L.
Grill, Joshua D.
Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study
title Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study
title_full Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study
title_fullStr Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study
title_full_unstemmed Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study
title_short Strategies Associated with Retaining Participants in the Longitudinal National Alzheimer’s Coordinating Center Uniform Data Set Study
title_sort strategies associated with retaining participants in the longitudinal national alzheimer’s coordinating center uniform data set study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277665/
https://www.ncbi.nlm.nih.gov/pubmed/35491778
http://dx.doi.org/10.3233/JAD-215537
work_keys_str_mv AT salazarchristianr strategiesassociatedwithretainingparticipantsinthelongitudinalnationalalzheimerscoordinatingcenteruniformdatasetstudy
AT ritchiemarina strategiesassociatedwithretainingparticipantsinthelongitudinalnationalalzheimerscoordinatingcenteruniformdatasetstudy
AT gillendaniell strategiesassociatedwithretainingparticipantsinthelongitudinalnationalalzheimerscoordinatingcenteruniformdatasetstudy
AT grilljoshuad strategiesassociatedwithretainingparticipantsinthelongitudinalnationalalzheimerscoordinatingcenteruniformdatasetstudy