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Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders

A new paradigm of cell therapy-based approaches as a solution to several diseases caused by damage or loss of cells/tissues leading to organ failure heralded the birth of a new branch in medicine called regenerative medicine (RM), which was further fueled by in vitro cell expansion and tissue engine...

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Autores principales: Preethy, Senthilkumar, Ranganathan, Natarajan, Raghavan, Kadalraja, Dedeepiya, Vidyasagar Devaprasad, Ikewaki, Nobunao, Abraham, Samuel J.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277691/
https://www.ncbi.nlm.nih.gov/pubmed/35466942
http://dx.doi.org/10.3233/JAD-220313
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author Preethy, Senthilkumar
Ranganathan, Natarajan
Raghavan, Kadalraja
Dedeepiya, Vidyasagar Devaprasad
Ikewaki, Nobunao
Abraham, Samuel J.K.
author_facet Preethy, Senthilkumar
Ranganathan, Natarajan
Raghavan, Kadalraja
Dedeepiya, Vidyasagar Devaprasad
Ikewaki, Nobunao
Abraham, Samuel J.K.
author_sort Preethy, Senthilkumar
collection PubMed
description A new paradigm of cell therapy-based approaches as a solution to several diseases caused by damage or loss of cells/tissues leading to organ failure heralded the birth of a new branch in medicine called regenerative medicine (RM), which was further fueled by in vitro cell expansion and tissue engineering (TE) technologies, including the ability to grow embryonic stem cells, induce pluripotent stem cells, and so on. RM addresses organ failure by repair, regeneration, or restoration, rejuvenation using cells, stem cells, or progenitor cells as tools having added cell-derived products also as a tool, and extracellular matrix component–based support, either direct or indirect (e.g., matrix induced autologous chondrocyte implantation) using scaffolds. Now, the main objective of RM is to solve the functional loss of cells that have evolved from cells as tools to cell-derived factors and scaffolds per se as tools. In this context, an important yet indispensable group of cells that constitute the major portion of the human body in terms of the number of cells having several essential roles to play, both directly and indirectly, starting from digestion and the immune system to the growing evidence of influencing neuronal function, aging, and carcinogenesis has been ignored. We would like to focus on these in this review as they should essentially be considered as a tool of RM, especially for neurological disorders for their vital role. What we are indicating is the second genome or the gut microbiome.
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spelling pubmed-92776912022-07-25 Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders Preethy, Senthilkumar Ranganathan, Natarajan Raghavan, Kadalraja Dedeepiya, Vidyasagar Devaprasad Ikewaki, Nobunao Abraham, Samuel J.K. J Alzheimers Dis Review A new paradigm of cell therapy-based approaches as a solution to several diseases caused by damage or loss of cells/tissues leading to organ failure heralded the birth of a new branch in medicine called regenerative medicine (RM), which was further fueled by in vitro cell expansion and tissue engineering (TE) technologies, including the ability to grow embryonic stem cells, induce pluripotent stem cells, and so on. RM addresses organ failure by repair, regeneration, or restoration, rejuvenation using cells, stem cells, or progenitor cells as tools having added cell-derived products also as a tool, and extracellular matrix component–based support, either direct or indirect (e.g., matrix induced autologous chondrocyte implantation) using scaffolds. Now, the main objective of RM is to solve the functional loss of cells that have evolved from cells as tools to cell-derived factors and scaffolds per se as tools. In this context, an important yet indispensable group of cells that constitute the major portion of the human body in terms of the number of cells having several essential roles to play, both directly and indirectly, starting from digestion and the immune system to the growing evidence of influencing neuronal function, aging, and carcinogenesis has been ignored. We would like to focus on these in this review as they should essentially be considered as a tool of RM, especially for neurological disorders for their vital role. What we are indicating is the second genome or the gut microbiome. IOS Press 2022-06-14 /pmc/articles/PMC9277691/ /pubmed/35466942 http://dx.doi.org/10.3233/JAD-220313 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Preethy, Senthilkumar
Ranganathan, Natarajan
Raghavan, Kadalraja
Dedeepiya, Vidyasagar Devaprasad
Ikewaki, Nobunao
Abraham, Samuel J.K.
Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders
title Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders
title_full Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders
title_fullStr Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders
title_full_unstemmed Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders
title_short Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders
title_sort integrating the synergy of the gut microbiome into regenerative medicine: relevance to neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277691/
https://www.ncbi.nlm.nih.gov/pubmed/35466942
http://dx.doi.org/10.3233/JAD-220313
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